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Toxicokinetics of pyrethroid metabolites in male and female rats. 2010

Jun Ueyama, and Naoko Hirosawa, and Aiko Mochizuki, and Akiko Kimata, and Michihiro Kamijima, and Takaaki Kondo, and Kenji Takagi, and Shinya Wakusawa, and Takaaki Hasegawa
Department of Medical Technology, Nagoya University School of Health Sciences, 1-1-20 Daikominami, Higashi-ku, Nagoya 461-8673, Japan.

The toxicokinetic characteristics of 3-phenoxybenzyl alcohol (3PBAlc) and 3-phenoxybenzaldehyde (3PBAld; metabolites of pyrethroid [PYR] after 25mg/kg, single intravenous administration), were investigated in male and female rats. The systemic clearance (Cl) of 3PBAlc in females (0.403±0.040l/h/kg) was significantly larger than that of males (0.227±0.036l/h/kg). The plasma concentration-time curve of 3PBAld decreased gradually and then increased again 1 and 2h after injection, suggesting the effect of enterohepatic circulation. The present study characterized the elimination and distribution of PYR metabolites and suggests that gender-related difference exists in the toxicokinetics of 3PBAlc and 3PBAld in rats.

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