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Toxicokinetics of naringin, a putative antitussive, after 184-day repeated oral administration in rats. 2011
Menghua Liu, and
Cuiping Yang, and
Wei Zou, and
Xiaoling Guan, and
Wenyan Zheng, and
Li Lai, and
Siqi Fang, and
Shuxing Cai, and
Weiwei Su
Guangzhou Quality R&D Center of Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
The toxicokinetic characteristics of naringin were investigated in rats that had been orally administered naringin extract, a candidate for oral treatment of cough, prepared from Citrus grandis "Tomentosa", at 50, 250, or 1250 mg/kg/day in a repeated-dose study for 1, 32, 93, or 184 days. Increased values of the mean systemic exposure were approximately proportional to increases in dose levels during all collection intervals; no saturation was observed. No significant differences in mean systemic exposure were observed between male and female rats. Results provide a reference for interpretation of toxicology findings and relevance to clinical safety issues.
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