The aim of this work was to study the effects of the dietary percentage of concentrate on patterns of intake, the evolution of rumen fermentation characteristics and plasma metabolites after a meal, nutrient digestibility, and milk production and composition in a medium-term trial in dairy goats. These effects have been well studied in dairy cattle but seldom in goats. Thirteen ruminally and duodenally cannulated dairy goats (95±4 d in milk) fed ad libitum were used in this study. Goats were assigned to 1 of 2 dietary treatments: high-concentrate (70% concentrate on dry matter basis) or a low-concentrate (35%) total mixed rations. The experiment was conducted over a period of 10 wk, including 3 wk of adaption to the diets. Patterns of intake, rumen fermentation characteristics, and plasma metabolites after a meal and fatty acids profile of milk fat were compared at the onset and at the end of the experiment. The increase in dietary percentage of concentrate decreased rumen pH, acetate to propionate ratio, ammonia-N concentration, and plasma urea concentration. The percentage of concentrate did not affect total volatile fatty acid concentrations. The high-concentrate diet increased the rate of intake during the morning meal at the onset of the experiment, whereas it decreased total dry matter intake and the rate of intake during the morning meal at the end of the experiment. The high-concentrate diet resulted in greater organic matter digestibility. Raw milk yield and protein yield were greater in goats fed the high-concentrate diet, whereas fat yield was not affected by dietary treatments. The milk fat content was lower in goats fed the high-concentrate diet. Proportions of the trans-C18:1 isomer relative to total fatty acids in milk were higher with the high-concentrate diet, but no modification of the proportion of total trans-C18:1 was detected, in particular no shift from trans-11 C18:1 to trans-10 C18:1 was observed. Further, the isomer trans-10,cis-12 C18:2 was not detected. Data from this study could be used for a new modeling approach or to improve existing models.