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Insulin and acute exercise (45 min of treadmill run) increased glucose uptake into perfused rat hindlimbs 5-fold and 3.2-fold, respectively. Following exercise, insulin treatment resulted in a further increase in glucose uptake. The subcellular distribution of the muscle glucose transporters GLUT-1 and GLUT-4 was determined in plasma membranes and intracellular membranes. Neither exercise nor exercise----insulin treatment altered the distribution of GLUT-1 transporters in these membrane fractions. In contrast, exercise, insulin and exercise----insulin treatment caused comparable increases in GLUT-4 transporters in the plasma membrane. The results suggest that exercise might limit insulin-induced GLUT-4 recruitment and that following exercise, insulin may alter the intrinsic activity of plasma membrane glucose transporters.
A G Douen, and
T Ramlal, and
G D Cartee, and
A Klip
December 1991,
The American journal of physiology,
A G Douen, and
T Ramlal, and
G D Cartee, and
A Klip
April 2003,
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A G Douen, and
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A G Douen, and
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A G Douen, and
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A G Douen, and
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A G Douen, and
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A G Douen, and
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A Klip
October 1990,
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A G Douen, and
T Ramlal, and
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A Klip
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The American journal of physiology,
A G Douen, and
T Ramlal, and
G D Cartee, and
A Klip
August 1993,
The American journal of physiology,
