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Immobilized carcinoembryonic antigen (CEA) and non-specific crossreacting antigen (NCA) bound 3 strains of E. coli of human origin. The binding was dose dependent, saturable, and of high avidity. Binding of the bacteria to CEA and NCA was completely abolished in the presence of 10 mM alpha-methyl D-mannopyranoside. Bacteria did not bind to concanavalin A. In addition, binding to deglycosylated CEA was either absent or significantly reduced. These findings indicate that the E. coli strains bind to D-mannosyl residues in CEA and NCA. Considering the tissue distribution of CEA (brush border of colonic epithelium) and NCA (granulocytes), these glycoproteins may be involved in the recognition of bacteria.
H G Leusch, and
S A Hefta, and
Z Drzeniek, and
K Hummel, and
Z Markos-Pusztai, and
C Wagener
January 1989,
Archivum immunologiae et therapiae experimentalis,
H G Leusch, and
S A Hefta, and
Z Drzeniek, and
K Hummel, and
Z Markos-Pusztai, and
C Wagener
January 1987,
Archivum immunologiae et therapiae experimentalis,
H G Leusch, and
S A Hefta, and
Z Drzeniek, and
K Hummel, and
Z Markos-Pusztai, and
C Wagener
October 1976,
British journal of cancer,
H G Leusch, and
S A Hefta, and
Z Drzeniek, and
K Hummel, and
Z Markos-Pusztai, and
C Wagener
January 1984,
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,
H G Leusch, and
S A Hefta, and
Z Drzeniek, and
K Hummel, and
Z Markos-Pusztai, and
C Wagener
July 1980,
European journal of cancer,
H G Leusch, and
S A Hefta, and
Z Drzeniek, and
K Hummel, and
Z Markos-Pusztai, and
C Wagener
July 1993,
British journal of cancer,
H G Leusch, and
S A Hefta, and
Z Drzeniek, and
K Hummel, and
Z Markos-Pusztai, and
C Wagener
January 1988,
Biochemical and biophysical research communications,
H G Leusch, and
S A Hefta, and
Z Drzeniek, and
K Hummel, and
Z Markos-Pusztai, and
C Wagener
January 1993,
British journal of cancer,
H G Leusch, and
S A Hefta, and
Z Drzeniek, and
K Hummel, and
Z Markos-Pusztai, and
C Wagener
January 1987,
Anticancer research,
H G Leusch, and
S A Hefta, and
Z Drzeniek, and
K Hummel, and
Z Markos-Pusztai, and
C Wagener
March 1984,
Clinica chimica acta; international journal of clinical chemistry,
