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This study tests the hypothesis that reactivation of a latent herpes simplex virus infection may be a cause of recurrent duodenal ulceration. Patients with recently healed duodenal ulcer were entered into a double blind, randomised study of maintenance treatment with the antiviral drug acyclovir (400 mg bid) versus placebo, to determine if suppression of herpes virus infection would influence the natural history of the ulcer disease. One hundred and fifteen patients entered the trial and 76 patients completed it according to the protocol. Endoscopy was performed when ulcer symptoms recurred and at the end of the 25 week trial period. In the acyclovir group the cumulated relapse rate was 63% compared with 56% in the placebo group (NS). This result suggests that reactivation of herpes simplex virus is not a cause of recurrent duodenal ulcer.
S J Rune, and
J Linde, and
O Bonnevie, and
H D Petersen, and
F Bendtsen, and
J H Wandall, and
C Gluud, and
J Eriksen, and
H Skovbjerg, and
M Vilien
November 1986,
Annals of internal medicine,
S J Rune, and
J Linde, and
O Bonnevie, and
H D Petersen, and
F Bendtsen, and
J H Wandall, and
C Gluud, and
J Eriksen, and
H Skovbjerg, and
M Vilien
January 1996,
The National medical journal of India,
S J Rune, and
J Linde, and
O Bonnevie, and
H D Petersen, and
F Bendtsen, and
J H Wandall, and
C Gluud, and
J Eriksen, and
H Skovbjerg, and
M Vilien
June 1987,
Therapeutische Umschau. Revue therapeutique,
S J Rune, and
J Linde, and
O Bonnevie, and
H D Petersen, and
F Bendtsen, and
J H Wandall, and
C Gluud, and
J Eriksen, and
H Skovbjerg, and
M Vilien
April 1988,
Zeitschrift fur Gastroenterologie. Verhandlungsband,
S J Rune, and
J Linde, and
O Bonnevie, and
H D Petersen, and
F Bendtsen, and
J H Wandall, and
C Gluud, and
J Eriksen, and
H Skovbjerg, and
M Vilien
January 1988,
Zeitschrift fur arztliche Fortbildung,
S J Rune, and
J Linde, and
O Bonnevie, and
H D Petersen, and
F Bendtsen, and
J H Wandall, and
C Gluud, and
J Eriksen, and
H Skovbjerg, and
M Vilien
April 1994,
Ugeskrift for laeger,
S J Rune, and
J Linde, and
O Bonnevie, and
H D Petersen, and
F Bendtsen, and
J H Wandall, and
C Gluud, and
J Eriksen, and
H Skovbjerg, and
M Vilien
March 1991,
Presse medicale (Paris, France : 1983),
S J Rune, and
J Linde, and
O Bonnevie, and
H D Petersen, and
F Bendtsen, and
J H Wandall, and
C Gluud, and
J Eriksen, and
H Skovbjerg, and
M Vilien
January 1990,
Gastroenterologie clinique et biologique,
S J Rune, and
J Linde, and
O Bonnevie, and
H D Petersen, and
F Bendtsen, and
J H Wandall, and
C Gluud, and
J Eriksen, and
H Skovbjerg, and
M Vilien
January 1994,
Klinicheskaia khirurgiia,
S J Rune, and
J Linde, and
O Bonnevie, and
H D Petersen, and
F Bendtsen, and
J H Wandall, and
C Gluud, and
J Eriksen, and
H Skovbjerg, and
M Vilien
September 1987,
The American journal of medicine,
