The potential role of metalloproteinases in neurogenesis in the gerbil hippocampus following global forebrain ischemia. 2011

Luiza Wójcik-Stanaszek, and Joanna Sypecka, and Patrycja Szymczak, and Malgorzata Ziemka-Nalecz, and Michel Khrestchatisky, and Santiago Rivera, and Teresa Zalewska
NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.

BACKGROUND Matrix metalloproteinases (MMPs) have recently been considered to be involved in the neurogenic response of adult neural stem/progenitor cells. However, there is a lack of information showing direct association between the activation of MMPs and the development of neuronal progenitor cells involving proliferation and/or further differentiation in vulnerable (Cornus Ammoni-CA1) and resistant (dentate gyrus-DG) to ischemic injury areas of the brain hippocampus. RESULTS We showed that dynamics of MMPs activation in the dentate gyrus correlated closely with the rate of proliferation and differentiation of progenitor cells into mature neurons. In contrast, in the damaged CA1 pyramidal cells layer, despite the fact that some proliferating cells exhibited antigen specific characteristic of newborn neuronal cells, these did not attain maturity. This coincides with the low, near control-level, activity of MMPs. The above results are supported by our in vitro study showing that MMP inhibitors interfered with both the proliferation and differentiation of the human neural stem cell line derived from umbilical cord blood (HUCB-NSCs) toward the neuronal lineage. CONCLUSIONS Taken together, the spatial and temporal profiles of MMPs activity suggest that these proteinases could be an important component in neurogenesis-associated processes in post-ischemic brain hippocampus.

UI MeSH Term Description Entries
D008297 Male Males
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D011480 Protease Inhibitors Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES). Antiprotease,Endopeptidase Inhibitor,Endopeptidase Inhibitors,Peptidase Inhibitor,Peptidase Inhibitors,Peptide Hydrolase Inhibitor,Peptide Hydrolase Inhibitors,Peptide Peptidohydrolase Inhibitor,Peptide Peptidohydrolase Inhibitors,Protease Antagonist,Protease Antagonists,Antiproteases,Protease Inhibitor,Antagonist, Protease,Antagonists, Protease,Hydrolase Inhibitor, Peptide,Hydrolase Inhibitors, Peptide,Inhibitor, Endopeptidase,Inhibitor, Peptidase,Inhibitor, Peptide Hydrolase,Inhibitor, Peptide Peptidohydrolase,Inhibitor, Protease,Inhibitors, Endopeptidase,Inhibitors, Peptidase,Inhibitors, Peptide Hydrolase,Inhibitors, Peptide Peptidohydrolase,Inhibitors, Protease,Peptidohydrolase Inhibitor, Peptide,Peptidohydrolase Inhibitors, Peptide
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D002545 Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION. Cerebral Ischemia,Ischemic Encephalopathy,Encephalopathy, Ischemic,Ischemia, Cerebral,Brain Ischemias,Cerebral Ischemias,Ischemia, Brain,Ischemias, Cerebral,Ischemic Encephalopathies
D005110 Extracellular Space Interstitial space between cells, occupied by INTERSTITIAL FLUID as well as amorphous and fibrous substances. For organisms with a CELL WALL, the extracellular space includes everything outside of the CELL MEMBRANE including the PERIPLASM and the cell wall. Intercellular Space,Extracellular Spaces,Intercellular Spaces,Space, Extracellular,Space, Intercellular,Spaces, Extracellular,Spaces, Intercellular
D005849 Gerbillinae A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys. Gerbils,Jird,Meriones,Psammomys,Rats, Sand,Gerbil,Jirds,Merione,Rat, Sand,Sand Rat,Sand Rats
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Luiza Wójcik-Stanaszek, and Joanna Sypecka, and Patrycja Szymczak, and Malgorzata Ziemka-Nalecz, and Michel Khrestchatisky, and Santiago Rivera, and Teresa Zalewska
January 2009, Acta neurobiologiae experimentalis,
Luiza Wójcik-Stanaszek, and Joanna Sypecka, and Patrycja Szymczak, and Malgorzata Ziemka-Nalecz, and Michel Khrestchatisky, and Santiago Rivera, and Teresa Zalewska
August 2016, Neural regeneration research,
Luiza Wójcik-Stanaszek, and Joanna Sypecka, and Patrycja Szymczak, and Malgorzata Ziemka-Nalecz, and Michel Khrestchatisky, and Santiago Rivera, and Teresa Zalewska
April 1994, Neuroscience letters,
Luiza Wójcik-Stanaszek, and Joanna Sypecka, and Patrycja Szymczak, and Malgorzata Ziemka-Nalecz, and Michel Khrestchatisky, and Santiago Rivera, and Teresa Zalewska
February 1994, Neuroscience letters,
Luiza Wójcik-Stanaszek, and Joanna Sypecka, and Patrycja Szymczak, and Malgorzata Ziemka-Nalecz, and Michel Khrestchatisky, and Santiago Rivera, and Teresa Zalewska
December 2000, Neurological research,
Luiza Wójcik-Stanaszek, and Joanna Sypecka, and Patrycja Szymczak, and Malgorzata Ziemka-Nalecz, and Michel Khrestchatisky, and Santiago Rivera, and Teresa Zalewska
February 2000, Brain research,
Luiza Wójcik-Stanaszek, and Joanna Sypecka, and Patrycja Szymczak, and Malgorzata Ziemka-Nalecz, and Michel Khrestchatisky, and Santiago Rivera, and Teresa Zalewska
December 1995, Neurological research,
Luiza Wójcik-Stanaszek, and Joanna Sypecka, and Patrycja Szymczak, and Malgorzata Ziemka-Nalecz, and Michel Khrestchatisky, and Santiago Rivera, and Teresa Zalewska
January 1996, Restorative neurology and neuroscience,
Luiza Wójcik-Stanaszek, and Joanna Sypecka, and Patrycja Szymczak, and Malgorzata Ziemka-Nalecz, and Michel Khrestchatisky, and Santiago Rivera, and Teresa Zalewska
January 2000, Journal of neural transmission (Vienna, Austria : 1996),
Luiza Wójcik-Stanaszek, and Joanna Sypecka, and Patrycja Szymczak, and Malgorzata Ziemka-Nalecz, and Michel Khrestchatisky, and Santiago Rivera, and Teresa Zalewska
January 2004, Neuroscience,
Copied contents to your clipboard!