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A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. 2011
James J Cronican, and
Kevin T Beier, and
Tina N Davis, and
Jen-Chieh Tseng, and
Weida Li, and
David B Thompson, and
Allen F Shih, and
Erin M May, and
Constance L Cepko, and
Andrew L Kung, and
Qiao Zhou, and
David R Liu
Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.
We discovered a class of naturally occurring human proteins with unusually high net positive charge that can potently deliver proteins in functional form into mammalian cells both in vitro and also in murine retina, pancreas, and white adipose tissues in vivo. These findings represent diverse macromolecule delivery agents for in vivo applications, and also raise the possibility that some of these human proteins may penetrate cells as part of their native biological functions.
Related Publications
James J Cronican, and
Kevin T Beier, and
Tina N Davis, and
Jen-Chieh Tseng, and
Weida Li, and
David B Thompson, and
Allen F Shih, and
Erin M May, and
Constance L Cepko, and
Andrew L Kung, and
Qiao Zhou, and
David R Liu
January 2009,
Archives of virology,
James J Cronican, and
Kevin T Beier, and
Tina N Davis, and
Jen-Chieh Tseng, and
Weida Li, and
David B Thompson, and
Allen F Shih, and
Erin M May, and
Constance L Cepko, and
Andrew L Kung, and
Qiao Zhou, and
David R Liu
January 1997,
Molekuliarnaia biologiia,
James J Cronican, and
Kevin T Beier, and
Tina N Davis, and
Jen-Chieh Tseng, and
Weida Li, and
David B Thompson, and
Allen F Shih, and
Erin M May, and
Constance L Cepko, and
Andrew L Kung, and
Qiao Zhou, and
David R Liu
August 1991,
Proceedings of the National Academy of Sciences of the United States of America,
James J Cronican, and
Kevin T Beier, and
Tina N Davis, and
Jen-Chieh Tseng, and
Weida Li, and
David B Thompson, and
Allen F Shih, and
Erin M May, and
Constance L Cepko, and
Andrew L Kung, and
Qiao Zhou, and
David R Liu
March 2002,
Cellular microbiology,
James J Cronican, and
Kevin T Beier, and
Tina N Davis, and
Jen-Chieh Tseng, and
Weida Li, and
David B Thompson, and
Allen F Shih, and
Erin M May, and
Constance L Cepko, and
Andrew L Kung, and
Qiao Zhou, and
David R Liu
March 2005,
Pharmaceutical research,
James J Cronican, and
Kevin T Beier, and
Tina N Davis, and
Jen-Chieh Tseng, and
Weida Li, and
David B Thompson, and
Allen F Shih, and
Erin M May, and
Constance L Cepko, and
Andrew L Kung, and
Qiao Zhou, and
David R Liu
December 2016,
The international journal of biochemistry & cell biology,
James J Cronican, and
Kevin T Beier, and
Tina N Davis, and
Jen-Chieh Tseng, and
Weida Li, and
David B Thompson, and
Allen F Shih, and
Erin M May, and
Constance L Cepko, and
Andrew L Kung, and
Qiao Zhou, and
David R Liu
January 2003,
Bioconjugate chemistry,
James J Cronican, and
Kevin T Beier, and
Tina N Davis, and
Jen-Chieh Tseng, and
Weida Li, and
David B Thompson, and
Allen F Shih, and
Erin M May, and
Constance L Cepko, and
Andrew L Kung, and
Qiao Zhou, and
David R Liu
October 2021,
Tissue & cell,
James J Cronican, and
Kevin T Beier, and
Tina N Davis, and
Jen-Chieh Tseng, and
Weida Li, and
David B Thompson, and
Allen F Shih, and
Erin M May, and
Constance L Cepko, and
Andrew L Kung, and
Qiao Zhou, and
David R Liu
February 1998,
Nucleic acids research,
James J Cronican, and
Kevin T Beier, and
Tina N Davis, and
Jen-Chieh Tseng, and
Weida Li, and
David B Thompson, and
Allen F Shih, and
Erin M May, and
Constance L Cepko, and
Andrew L Kung, and
Qiao Zhou, and
David R Liu
June 2003,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
