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Synthesis and anti-human immunodeficiency virus activity of the skeleton isomers of 3',4'-Di-(O)-(-)-camphanoyl-(+)-khellactone. 2011
Hiromi Nishioka, and
Koji Uesugi, and
Norihiro Ueda, and
Yuka Kondo, and
Megumi Tsuji, and
Hitoshi Abe, and
Takashi Harayama, and
Takayuki Hamasaki, and
Masanori Baba, and
Yasuo Takeuchi
Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.
Optically active structural isomers (1b-f and dst-1b-f) of 3',4'-di-(O)-(-)-camphanoyl-(+)-khellactone (DCK) were synthesized and their anti-human immunodeficiency virus (HIV) activity was investigated. The value of the sensitivity index (SI) of 1b was greater than that of DCK.
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