Sweep pattern visual evoked potential acuity in children during their periods of visual development. 2011

Lu Li, and Yu Su, and Chang-zheng Chen, and Chao Feng, and Hong-mei Zheng, and Yi-qiao Xing
Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.

OBJECTIVE To study the clinical usage of sweep pattern visual evoked potential (SPVEP) acuity in children's visual development periods and compare the amplitude-spatial frequency (A-SP) function regression method with the amplitude-logarithm of the visual angle (A-logVA) function regression method in evaluating the SPVEP acuity of children, especially those who have poor visual acuities. METHODS Twenty-six eyes of 26 amblyopic children (ages ranged from 3 to 12 years; mean age±standard deviation 6.69±1.74 years) and 31 eyes of normal children whose ages were matched with the amblyopic group were involved in this study. SPVEP acuity was recorded with GT-2000 NV (Guote Medical Apparatus Ltd., China) using sinusoidally modulated horizontal gratings with 10 different spatial frequencies from 0.99 to 12.89 cycles per degree to stimulate the retina. The averaging responses were displayed with the discrete Fourier transformation method. SPVEP acuity was assessed by both the A-SP function regression method and the A-logVA function regression method. The logarithm of minimal angle of resolution (logMAR) chart was used to obtain logMAR visual acuity. RESULTS In the normal group, logMAR acuity calculated by both the A-SP and A-logVA function regression methods had a significant correlation with SPVEP acuity. The average value of SPVEP acuity (by A-logVA) was closer to logMAR acuity. The difference of mean values between logMAR acuity and SPVEP acuity was significant in both regression methods. In the amblyopic group, it was SPVEP acuity (by A-logVA) that had a significant correlation with logMAR acuity, whereas the result was not significant when calculated by the A-SP function regression method (p=0.515). The average value of SPVEP acuity (A-SP) was closer to logMAR acuity. The difference of mean values between logMAR acuity and SPVEP acuity (A-logVA) was significant; however, when compared with SPVEP acuity (A-SP), it was not significant (p=0.174). In addition, SPVEP acuity may be overestimated or underestimated when it is compared with different logMAR visual acuities. CONCLUSIONS SPVEP could be used to evaluate the visual acuity for normal children or those with poor visual acuity. Moreover, the A-logVA function regression method was more accurate than the A-SP function regression method in evaluating SPVEP acuity.

UI MeSH Term Description Entries
D008297 Male Males
D012030 Refractive Errors Deviations from the average or standard indices of refraction of the eye through its dioptric or refractive apparatus. Ametropia,Refractive Disorders,Ametropias,Disorder, Refractive,Disorders, Refractive,Error, Refractive,Errors, Refractive,Refractive Disorder,Refractive Error
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005074 Evoked Potentials, Visual The electric response evoked in the cerebral cortex by visual stimulation or stimulation of the visual pathways. Visual Evoked Response,Evoked Potential, Visual,Evoked Response, Visual,Evoked Responses, Visual,Potential, Visual Evoked,Potentials, Visual Evoked,Response, Visual Evoked,Responses, Visual Evoked,Visual Evoked Potential,Visual Evoked Potentials,Visual Evoked Responses
D005123 Eye The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light. Eyes
D005260 Female Females
D005583 Fourier Analysis Analysis based on the mathematical function first formulated by Jean-Baptiste-Joseph Fourier in 1807. The function, known as the Fourier transform, describes the sinusoidal pattern of any fluctuating pattern in the physical world in terms of its amplitude and its phase. It has broad applications in biomedicine, e.g., analysis of the x-ray crystallography data pivotal in identifying the double helical nature of DNA and in analysis of other molecules, including viruses, and the modified back-projection algorithm universally used in computerized tomography imaging, etc. (From Segen, The Dictionary of Modern Medicine, 1992) Fourier Series,Fourier Transform,Analysis, Cyclic,Analysis, Fourier,Cyclic Analysis,Analyses, Cyclic,Cyclic Analyses,Series, Fourier,Transform, Fourier
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000550 Amblyopia A nonspecific term referring to impaired vision. Major subcategories include stimulus deprivation-induced amblyopia and toxic amblyopia. Stimulus deprivation-induced amblyopia is a developmental disorder of the visual cortex. A discrepancy between visual information received by the visual cortex from each eye results in abnormal cortical development. STRABISMUS and REFRACTIVE ERRORS may cause this condition. Toxic amblyopia is a disorder of the OPTIC NERVE which is associated with ALCOHOLISM, tobacco SMOKING, and other toxins and as an adverse effect of the use of some medications. Anisometropic Amblyopia,Lazy Eye,Amblyopia, Developmental,Amblyopia, Stimulus Deprivation-Induced,Amblyopia, Suppression,Stimulus Deprivation-Induced Amblyopia,Amblyopia, Anisometropic,Amblyopia, Stimulus Deprivation Induced,Amblyopias,Amblyopias, Anisometropic,Amblyopias, Developmental,Amblyopias, Stimulus Deprivation-Induced,Amblyopias, Suppression,Anisometropic Amblyopias,Deprivation-Induced Amblyopia, Stimulus,Deprivation-Induced Amblyopias, Stimulus,Developmental Amblyopia,Developmental Amblyopias,Eye, Lazy,Eyes, Lazy,Lazy Eyes,Stimulus Deprivation Induced Amblyopia,Stimulus Deprivation-Induced Amblyopias,Suppression Amblyopia,Suppression Amblyopias

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