-transparent.png){kind=logo}
Seventy-six participants were enrolled in a clinical trial to determine therapeutic effectiveness of 3 percent vidarabine applied topically to recurrent perioral herpetic lesions. Following a 6- to- 12-month natural history phase, a 12-month clinical trial was conducted. Seventy participants developed 463 lesions during 361 episodes. Three percent vidarabine in a water-miscible gel was applied six times daily for 7 days to each lesion in the experimental group. Identically packaged placebo was used by the control group. Group assignment was by computer-generated randomization. Lesion size was reduced when vidarabine, rather than placebo, was applied. The difference was statistically significant (Student's t test, P = 0.02). Vesiculation followed tingling more rapidly when vidarabine, rather than placebo, was applied prior to vesiculation (P = 0.05). No significant difference between the two groups was found in episode frequency or lesion duration. Adverse reactions to vidarabine were not experienced.
N H Rowe, and
S L Brooks, and
S K Young, and
J Spencer, and
T J Petrick, and
R A Buchanan, and
J C Drach, and
C Shipman
June 1988,
The Journal of antimicrobial chemotherapy,
N H Rowe, and
S L Brooks, and
S K Young, and
J Spencer, and
T J Petrick, and
R A Buchanan, and
J C Drach, and
C Shipman
July 1973,
Deutsche medizinische Wochenschrift (1946),
N H Rowe, and
S L Brooks, and
S K Young, and
J Spencer, and
T J Petrick, and
R A Buchanan, and
J C Drach, and
C Shipman
July 1988,
Den Norske tannlaegeforenings tidende,
N H Rowe, and
S L Brooks, and
S K Young, and
J Spencer, and
T J Petrick, and
R A Buchanan, and
J C Drach, and
C Shipman
October 2023,
EClinicalMedicine,
N H Rowe, and
S L Brooks, and
S K Young, and
J Spencer, and
T J Petrick, and
R A Buchanan, and
J C Drach, and
C Shipman
September 2014,
Journal of drugs in dermatology : JDD,
N H Rowe, and
S L Brooks, and
S K Young, and
J Spencer, and
T J Petrick, and
R A Buchanan, and
J C Drach, and
C Shipman
January 1996,
BMJ (Clinical research ed.),
N H Rowe, and
S L Brooks, and
S K Young, and
J Spencer, and
T J Petrick, and
R A Buchanan, and
J C Drach, and
C Shipman
January 1989,
RDH,
N H Rowe, and
S L Brooks, and
S K Young, and
J Spencer, and
T J Petrick, and
R A Buchanan, and
J C Drach, and
C Shipman
January 1978,
The American journal of the medical sciences,
N H Rowe, and
S L Brooks, and
S K Young, and
J Spencer, and
T J Petrick, and
R A Buchanan, and
J C Drach, and
C Shipman
January 2001,
Oral diseases,
N H Rowe, and
S L Brooks, and
S K Young, and
J Spencer, and
T J Petrick, and
R A Buchanan, and
J C Drach, and
C Shipman
March 2021,
Photodiagnosis and photodynamic therapy,
