Pathogenesis of experimental amyloid protein A amyloidosis in sore hocks-affected rabbits. 2011

Tomoaki Murakami, and Yasuo Inoshima, and Ken-Ichi Watanabe, and Yoshiyasu Kobayashi, and Takane Matsui, and Hisao Kurazono, and Naotaka Ishiguro
United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan.

Although the experimental transmission of amyloid protein A (AA) amyloidosis with amyloid-enhancing factor has been studied intensively, its pathogenesis remains obscure. We previously found that rabbits affected with 'sore hocks' (SH) uniquely developed AA amyloidosis in response to primary inflammatory stimulation followed by the administration of bovine AA fibrils. However, it is unknown why only the rabbits with preexisting SH developed experimental AA amyloidosis. There may be hidden factors in the SH status that stimulate the mechanism of cross-species transmission of AA amyloidosis. To examine the essential factors in the development of experimental AA amyloidosis in SH-affected rabbits, we studied the etiology of SH in rabbits pathologically and bacteriologically. In addition, we developed artificial SH symptoms in normal rabbits by use of an adjuvant prepared from Staphylococcus aureus (StA) isolated from a spontaneous SH-affected rabbit, and we evaluated the incidence of AA amyloidosis in rabbits with or without experimental SH symptoms. We found that StA administration was extremely efficient at stimulating the induction of experimental AA amyloidosis, and the influence of SH was required. We found that the persistent S. aureus infection in SH facilitates the development of experimental AA amyloidosis in rabbits and that the inflammatory stimulation provided by SH acts as an additional accelerator in experimental AA amyloidosis.

UI MeSH Term Description Entries
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D005533 Foot Dermatoses Skin diseases of the foot, general or unspecified. Foot Dermatosis,Dermatoses, Foot,Dermatosis, Foot
D000685 Serum Amyloid A Protein An ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS. Amyloid Protein SAA,Amyloid Serum Protein SAA,Serum A Related Protein,Amyloid A Precursor,Amyloid A Protein,Amyloid A Protein-Related Serum Component,Amyloid Fibril Protein AA,Amyloid Protein AA,Amyloid Protein AA Precursor,Amyloid-Related Serum Protein (SAA),Serum Amyloid A,Serum Amyloid Protein A,Amyloid A Protein Related Serum Component
D000686 Amyloidosis A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits. Amyloidoses
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013207 Staphylococcal Skin Infections Infections to the skin caused by bacteria of the genus STAPHYLOCOCCUS. Skin Diseases, Staphylococcal,Infections, Staphylococcal Skin,Skin Infections, Staphylococcal,Staphylococcal Diseases, Skin,Staphylococcal Infections, Skin,Staphylococcal Skin Diseases
D013211 Staphylococcus aureus Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
D016523 Foot Ulcer Lesion on the surface of the skin of the foot, usually accompanied by inflammation. The lesion may become infected or necrotic and is frequently associated with diabetes or leprosy. Plantar Ulcer,Foot Ulcers,Plantar Ulcers,Ulcer, Foot,Ulcer, Plantar,Ulcers, Foot,Ulcers, Plantar

Related Publications

Tomoaki Murakami, and Yasuo Inoshima, and Ken-Ichi Watanabe, and Yoshiyasu Kobayashi, and Takane Matsui, and Hisao Kurazono, and Naotaka Ishiguro
June 2008, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis,
Tomoaki Murakami, and Yasuo Inoshima, and Ken-Ichi Watanabe, and Yoshiyasu Kobayashi, and Takane Matsui, and Hisao Kurazono, and Naotaka Ishiguro
April 1977, Laboratory investigation; a journal of technical methods and pathology,
Tomoaki Murakami, and Yasuo Inoshima, and Ken-Ichi Watanabe, and Yoshiyasu Kobayashi, and Takane Matsui, and Hisao Kurazono, and Naotaka Ishiguro
July 2001, Lancet (London, England),
Tomoaki Murakami, and Yasuo Inoshima, and Ken-Ichi Watanabe, and Yoshiyasu Kobayashi, and Takane Matsui, and Hisao Kurazono, and Naotaka Ishiguro
January 1973, Scandinavian journal of rheumatology,
Tomoaki Murakami, and Yasuo Inoshima, and Ken-Ichi Watanabe, and Yoshiyasu Kobayashi, and Takane Matsui, and Hisao Kurazono, and Naotaka Ishiguro
December 1984, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
Tomoaki Murakami, and Yasuo Inoshima, and Ken-Ichi Watanabe, and Yoshiyasu Kobayashi, and Takane Matsui, and Hisao Kurazono, and Naotaka Ishiguro
December 1968, Danish medical bulletin,
Tomoaki Murakami, and Yasuo Inoshima, and Ken-Ichi Watanabe, and Yoshiyasu Kobayashi, and Takane Matsui, and Hisao Kurazono, and Naotaka Ishiguro
January 1950, Deutsches Archiv fur klinische Medizin,
Tomoaki Murakami, and Yasuo Inoshima, and Ken-Ichi Watanabe, and Yoshiyasu Kobayashi, and Takane Matsui, and Hisao Kurazono, and Naotaka Ishiguro
March 1998, Proceedings of the National Academy of Sciences of the United States of America,
Tomoaki Murakami, and Yasuo Inoshima, and Ken-Ichi Watanabe, and Yoshiyasu Kobayashi, and Takane Matsui, and Hisao Kurazono, and Naotaka Ishiguro
December 1966, The American journal of pathology,
Tomoaki Murakami, and Yasuo Inoshima, and Ken-Ichi Watanabe, and Yoshiyasu Kobayashi, and Takane Matsui, and Hisao Kurazono, and Naotaka Ishiguro
February 1967, Acta pathologica japonica,
Copied contents to your clipboard!