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Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. 2011
Meng Li, and
Hong Zhao, and
Xiaosong Zhang, and
Laura D Wood, and
Robert A Anders, and
Michael A Choti, and
Timothy M Pawlik, and
Hubert D Daniel, and
Rajesh Kannangai, and
G Johan A Offerhaus, and
Victor E Velculescu, and
Linfang Wang, and
Shibin Zhou, and
Bert Vogelstein, and
Ralph H Hruban, and
Nick Papadopoulos, and
Jianqiang Cai, and
Michael S Torbenson, and
Kenneth W Kinzler
Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype.
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