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One hundred and twelve subcutaneous injections of concentrated heparin (25,000 IU/ml), half in sodium heparin and half in calciparine, both with an identical heparin cation, were given in doses varying from 0.2 ml to 0.5 ml by a single operator in a double-blind study to assess the comparative local tolerance of the two heparin salts. The occurrence of bruising at the point of injection, more frequent with sodium heparin than with Calciparine, proved to be the distinguishing factor. Overall after 48 hours, 31 hematomas were observed with the sodium salt versus 20 with calciparine. McNemar's test of comparing matched proportions confirms this result (p = 0.03) and, with the order of the two treatments taken into consideration, J.J. Gart's exact test gives p = 0.0101.
J M Blard, and
F Rincon, and
J P Nakache, and
C Chastang
December 1975,
Haematologica,
J M Blard, and
F Rincon, and
J P Nakache, and
C Chastang
February 1980,
Clinical pharmacology and therapeutics,
J M Blard, and
F Rincon, and
J P Nakache, and
C Chastang
January 1984,
Clinical pharmacy,
J M Blard, and
F Rincon, and
J P Nakache, and
C Chastang
February 1982,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
J M Blard, and
F Rincon, and
J P Nakache, and
C Chastang
October 1978,
Thrombosis and haemostasis,
J M Blard, and
F Rincon, and
J P Nakache, and
C Chastang
January 1978,
Acta psychiatrica Belgica,
J M Blard, and
F Rincon, and
J P Nakache, and
C Chastang
January 1979,
Annales pharmaceutiques francaises,
J M Blard, and
F Rincon, and
J P Nakache, and
C Chastang
April 1982,
Deutsche medizinische Wochenschrift (1946),
J M Blard, and
F Rincon, and
J P Nakache, and
C Chastang
January 1981,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
J M Blard, and
F Rincon, and
J P Nakache, and
C Chastang
April 1982,
Zhonghua wai ke za zhi [Chinese journal of surgery],
