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Polymerase chain reaction (PCR) amplification followed by oligonucleotide probing was used to investigate the presence of ras genes mutations in human thyroid adenomas and carcinomas. The results confirm the frequent occurrence of mutations in all three ras genes in both adenomas and carcinomas, in agreement with the hypothesis that the ras mutations may constitute early steps in thyroid tumorigenesis. No evident correlation between the frequency of ras mutations, the identity of the mutated ras gene, the position affected in the ras gene or the type of mutation and the pathological features is apparent. However, definitive conclusion on this point is precluded because of the small number of tumors examined at the present time.
H G Suarez, and
J A du Villard, and
M Severino, and
B Caillou, and
M Schlumberger, and
M Tubiana, and
C Parmentier, and
R Monier
September 1995,
International journal of oncology,
H G Suarez, and
J A du Villard, and
M Severino, and
B Caillou, and
M Schlumberger, and
M Tubiana, and
C Parmentier, and
R Monier
August 1995,
Japanese journal of cancer research : Gann,
H G Suarez, and
J A du Villard, and
M Severino, and
B Caillou, and
M Schlumberger, and
M Tubiana, and
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January 1992,
Progress in clinical and biological research,
H G Suarez, and
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M Schlumberger, and
M Tubiana, and
C Parmentier, and
R Monier
April 1992,
The Journal of clinical endocrinology and metabolism,
H G Suarez, and
J A du Villard, and
M Severino, and
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M Tubiana, and
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R Monier
August 1995,
Oncogene,
H G Suarez, and
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May 1988,
Biochimica et biophysica acta,
H G Suarez, and
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M Schlumberger, and
M Tubiana, and
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R Monier
June 2003,
The Journal of clinical endocrinology and metabolism,
H G Suarez, and
J A du Villard, and
M Severino, and
B Caillou, and
M Schlumberger, and
M Tubiana, and
C Parmentier, and
R Monier
January 1994,
World journal of surgery,
H G Suarez, and
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B Caillou, and
M Schlumberger, and
M Tubiana, and
C Parmentier, and
R Monier
July 1990,
The Journal of clinical endocrinology and metabolism,
H G Suarez, and
J A du Villard, and
M Severino, and
B Caillou, and
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M Tubiana, and
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R Monier
November 1993,
International journal of cancer,
