-transparent.png){kind=logo}
Methylation has been implicated in the etiology of psychiatric illness. Parenteral S-adenosylmethionine, a methyl group donor, has been shown to be an effective antidepressant. The authors studied the antidepressant effect of oral S-adenosylmethionine in a randomized, double-blind, placebo-controlled trial for 15 inpatients with major depression. The results suggest that oral S-adenosylmethionine is a safe, effective antidepressant with few side effects and a rapid onset of action. S-Adenosylmethionine induced mania in a patient with no history of mania. S-Adenosylmethionine may be useful for patients who cannot tolerate tricyclic anti-depressants. These findings support a role for methylation in the pathophysiology of depression.
B L Kagan, and
D L Sultzer, and
N Rosenlicht, and
R H Gerner
June 1999,
Journal of hepatology,
B L Kagan, and
D L Sultzer, and
N Rosenlicht, and
R H Gerner
May 2000,
Diabetes care,
B L Kagan, and
D L Sultzer, and
N Rosenlicht, and
R H Gerner
July 1990,
Gastroenterology,
B L Kagan, and
D L Sultzer, and
N Rosenlicht, and
R H Gerner
November 1987,
The American journal of medicine,
B L Kagan, and
D L Sultzer, and
N Rosenlicht, and
R H Gerner
May 2011,
Psychopharmacology bulletin,
B L Kagan, and
D L Sultzer, and
N Rosenlicht, and
R H Gerner
November 2014,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
B L Kagan, and
D L Sultzer, and
N Rosenlicht, and
R H Gerner
March 2014,
Psychopharmacology,
B L Kagan, and
D L Sultzer, and
N Rosenlicht, and
R H Gerner
May 2014,
Journal of psychiatric research,
B L Kagan, and
D L Sultzer, and
N Rosenlicht, and
R H Gerner
May 1994,
The Journal of rheumatology,
B L Kagan, and
D L Sultzer, and
N Rosenlicht, and
R H Gerner
January 2020,
Psychopharmacology,
