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Immunogenicity of smallpox vaccines prepared of EM-63, L-IVP, and B-51 strains was studied under conditions of strict controlled epidemiological trial. Skin reactions to revaccination and vaccines antigenic activity indices were detemined in the persons vaccinated. Changes in the virus-neutralizing and antibodies suppressing hemagglutination was the same in persons vaccinated with any of the preparations tested. The maximal virus-neutralizing antibodies level was determined 1 month after the vaccination and persisted without any essential changes for one year. The titre of hemagglutination inhibiting antibodies also reached the maximum in one month, but diminished gradually by the end of one year after the vaccination. There were found no significant differences in the antigenic activity of the vaccines. The vaccines studied also displayed no difference in the number and character of skin reactions to revaccination. In comparing the antibodies level and the character of skin reactions to revaccination it was found that the titres of hemagglutination inhibiting antibodies and virus-neutralizing antibodies of 1:40 and over were in the great majority of cases determined in the blood sera of the vaccinated persons with the immediate and negative reactions to revaccination, i. e. in those with intensive postvaccinal immunity.
G N Khliabich, and
A A Sumarokov, and
G A Karinskaia, and
R Ia Shkol'nik, and
N V Iaroslavskaia
January 1959,
Bulletin of the World Health Organization,
G N Khliabich, and
A A Sumarokov, and
G A Karinskaia, and
R Ia Shkol'nik, and
N V Iaroslavskaia
January 1971,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
G N Khliabich, and
A A Sumarokov, and
G A Karinskaia, and
R Ia Shkol'nik, and
N V Iaroslavskaia
November 1974,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
G N Khliabich, and
A A Sumarokov, and
G A Karinskaia, and
R Ia Shkol'nik, and
N V Iaroslavskaia
October 1990,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
G N Khliabich, and
A A Sumarokov, and
G A Karinskaia, and
R Ia Shkol'nik, and
N V Iaroslavskaia
January 1972,
Acta microbiologica Academiae Scientiarum Hungaricae,
G N Khliabich, and
A A Sumarokov, and
G A Karinskaia, and
R Ia Shkol'nik, and
N V Iaroslavskaia
January 1987,
Postgraduate medical journal,
G N Khliabich, and
A A Sumarokov, and
G A Karinskaia, and
R Ia Shkol'nik, and
N V Iaroslavskaia
January 1972,
Medicina,
G N Khliabich, and
A A Sumarokov, and
G A Karinskaia, and
R Ia Shkol'nik, and
N V Iaroslavskaia
June 1989,
Vaccine,
G N Khliabich, and
A A Sumarokov, and
G A Karinskaia, and
R Ia Shkol'nik, and
N V Iaroslavskaia
January 1993,
Voprosy virusologii,
G N Khliabich, and
A A Sumarokov, and
G A Karinskaia, and
R Ia Shkol'nik, and
N V Iaroslavskaia
February 1970,
Zeitschrift fur die gesamte Hygiene und ihre Grenzgebiete,
