The effect of resveratrol on blood pressure in a rat model of preeclampsia. 2012

Ozlem Moraloglu, and Yaprak Engin-Ustun, and Esra Tonguç, and Turgut Var, and Omer Lütfü Tapisiz, and Hakan Ergün, and Tolga Guvenc, and Ayhan Gacar
Zekai Tahir Burak Woman's Health Education and Research Hospital, Department of Perinatology, Ankara, Turkey. ozlem.moraloglu@hotmail.com

OBJECTIVE To examine the hypothesis that resveratrol administration could result in blood pressure and blood flow decrease in a rat preeclampsia model. METHODS Desoxycorticosterone acetate (DOCA) was used to produce hypertension. The Wistar albino rats were divided randomly into three groups: control (n = 12), DOCA injected (n = 11), and DOCA injected and resveratrol treated (n = 13). Rats were sacrificed on gestational day 16-20. The systolic blood pressure was measured by the tail-cuff method. Urine protein was expressed as protein/creatinine. Laser Doppler measurements of the blood flow were made in one placenta, the left kidney and both parietal lobes of brain. Placentas were examined by light microscopy. RESULTS DOCA injected group exhibited significant differences in blood pressure and protein/creatinine. Mean blood pressure in DOCA-treated rats was 130.1 ± 12.9 mmHg at baseline and 148.4 ± 20.1 mmHg at the time of euthanization (p = 0.044). Resveratrol did not significantly affect blood pressure, placental and renal blood flows. There were also no significant differences in placental pathology parameters among the three groups. CONCLUSIONS The present study demonstrated that resveratrol did not decrease blood pressure, and did not result in a significant response in blood flows and placental pathology parameters.

UI MeSH Term Description Entries
D008297 Male Males
D011225 Pre-Eclampsia A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease. Toxemias, Pregnancy,EPH Complex,EPH Gestosis,EPH Toxemias,Edema-Proteinuria-Hypertension Gestosis,Gestosis, EPH,Hypertension-Edema-Proteinuria Gestosis,Preeclampsia,Preeclampsia Eclampsia 1,Pregnancy Toxemias,Proteinuria-Edema-Hypertension Gestosis,Toxemia Of Pregnancy,1, Preeclampsia Eclampsia,1s, Preeclampsia Eclampsia,EPH Toxemia,Eclampsia 1, Preeclampsia,Eclampsia 1s, Preeclampsia,Edema Proteinuria Hypertension Gestosis,Gestosis, Edema-Proteinuria-Hypertension,Gestosis, Hypertension-Edema-Proteinuria,Gestosis, Proteinuria-Edema-Hypertension,Hypertension Edema Proteinuria Gestosis,Of Pregnancies, Toxemia,Of Pregnancy, Toxemia,Pre Eclampsia,Preeclampsia Eclampsia 1s,Pregnancies, Toxemia Of,Pregnancy Toxemia,Pregnancy, Toxemia Of,Proteinuria Edema Hypertension Gestosis,Toxemia Of Pregnancies,Toxemia, EPH,Toxemia, Pregnancy,Toxemias, EPH
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D012079 Renal Circulation The circulation of the BLOOD through the vessels of the KIDNEY. Kidney Circulation,Renal Blood Flow,Circulation, Kidney,Circulation, Renal,Blood Flow, Renal,Flow, Renal Blood
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004353 Drug Evaluation, Preclinical Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications. Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D005260 Female Females
D000077185 Resveratrol A stilbene and non-flavonoid polyphenol produced by various plants including grapes and blueberries. It has anti-oxidant, anti-inflammatory, cardioprotective, anti-mutagenic, and anti-carcinogenic properties. It also inhibits platelet aggregation and the activity of several DNA HELICASES in vitro. 3,4',5-Stilbenetriol,3,4',5-Trihydroxystilbene,3,5,4'-Trihydroxystilbene,Resveratrol, (Z)-,Resveratrol-3-sulfate,SRT 501,SRT-501,SRT501,cis-Resveratrol,trans-Resveratrol,trans-Resveratrol-3-O-sulfate,Resveratrol 3 sulfate,cis Resveratrol,trans Resveratrol,trans Resveratrol 3 O sulfate
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Ozlem Moraloglu, and Yaprak Engin-Ustun, and Esra Tonguç, and Turgut Var, and Omer Lütfü Tapisiz, and Hakan Ergün, and Tolga Guvenc, and Ayhan Gacar
September 1999, American journal of obstetrics and gynecology,
Ozlem Moraloglu, and Yaprak Engin-Ustun, and Esra Tonguç, and Turgut Var, and Omer Lütfü Tapisiz, and Hakan Ergün, and Tolga Guvenc, and Ayhan Gacar
May 1999, American journal of obstetrics and gynecology,
Ozlem Moraloglu, and Yaprak Engin-Ustun, and Esra Tonguç, and Turgut Var, and Omer Lütfü Tapisiz, and Hakan Ergün, and Tolga Guvenc, and Ayhan Gacar
February 2023, Acta biochimica Polonica,
Ozlem Moraloglu, and Yaprak Engin-Ustun, and Esra Tonguç, and Turgut Var, and Omer Lütfü Tapisiz, and Hakan Ergün, and Tolga Guvenc, and Ayhan Gacar
January 2018, Methods in molecular biology (Clifton, N.J.),
Ozlem Moraloglu, and Yaprak Engin-Ustun, and Esra Tonguç, and Turgut Var, and Omer Lütfü Tapisiz, and Hakan Ergün, and Tolga Guvenc, and Ayhan Gacar
October 2014, Yao xue xue bao = Acta pharmaceutica Sinica,
Ozlem Moraloglu, and Yaprak Engin-Ustun, and Esra Tonguç, and Turgut Var, and Omer Lütfü Tapisiz, and Hakan Ergün, and Tolga Guvenc, and Ayhan Gacar
December 1961, Lancet (London, England),
Ozlem Moraloglu, and Yaprak Engin-Ustun, and Esra Tonguç, and Turgut Var, and Omer Lütfü Tapisiz, and Hakan Ergün, and Tolga Guvenc, and Ayhan Gacar
November 2022, Marine drugs,
Ozlem Moraloglu, and Yaprak Engin-Ustun, and Esra Tonguç, and Turgut Var, and Omer Lütfü Tapisiz, and Hakan Ergün, and Tolga Guvenc, and Ayhan Gacar
January 2018, Prostaglandins & other lipid mediators,
Ozlem Moraloglu, and Yaprak Engin-Ustun, and Esra Tonguç, and Turgut Var, and Omer Lütfü Tapisiz, and Hakan Ergün, and Tolga Guvenc, and Ayhan Gacar
June 2017, Neuroscience bulletin,
Ozlem Moraloglu, and Yaprak Engin-Ustun, and Esra Tonguç, and Turgut Var, and Omer Lütfü Tapisiz, and Hakan Ergün, and Tolga Guvenc, and Ayhan Gacar
August 2018, The Malaysian journal of pathology,
Copied contents to your clipboard!