Biomaterial Database

Clinical parameters of circadian rhythms in affective disorders. 2011

Jan Scott

Academic Psychiatry, Institute of Neuroscience, Newcastle University, UK. jan.scott@newcastle.ac.uk

Many affective disorders show episode cycling and the classic symptoms of these disorders show rhythmicity, such as diurnal variation in mood. There are several plausible stress-vulnerability models that suggest links between these observed phenomena and the circadian system. For example, an individual with increased sensitivity to social rhythm disruption may be more at risk of circadian rhythm (CR) dysregulation. Furthermore, there are hypothesized neurobiological mechanisms that may explain how CR dysregulation might lead to sleep, activation, and mood changes in unipolar and bipolar disorders. There are gaps in our understanding, but this paper highlights that clinical measures of sleep and activation are increasingly useful for monitoring the onset and course of affective disorders. Also, evidence suggests that CR disruptions may represent core elements not simply epiphenomena of affective disorders.

UI	MeSH Term	Description	Entries
D002940	Circadian Rhythm	The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.	Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012890	Sleep	A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.	Sleep Habits,Sleeping Habit,Sleeping Habits,Habit, Sleep,Habit, Sleeping,Habits, Sleep,Habits, Sleeping,Sleep Habit
D019964	Mood Disorders	Those disorders that have a disturbance in mood as their predominant feature.	Affective Disorders,Affective Disorder,Disorder, Affective,Disorder, Mood,Disorders, Affective,Disorders, Mood,Mood Disorder
D021081	Chronobiology Disorders	Disruptions of the rhythmic cycle of bodily functions or activities.	Circadian Rhythm Disorders,Biological Clock Disturbances,Circadian Dysregulation,Inversion of Circadian Rhythm, Psychogenic,Psychogenic Inversion of Circadian Rhythm,Biological Clock Disturbance,Chronobiology Disorder,Circadian Rhythm Disorder,Disturbance, Biological Clock,Disturbances, Biological Clock,Dysregulation, Circadian