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One hundred patients with moderate to severe atopic dermatitis were entered into a two-center, double-blind trial. Patients were randomized to receive either thymopentin (Timunox, n = 48) or placebo (n = 52), administered as daily subcutaneous injections for 6 weeks. Clinical extent of disease and severity parameters were measured at baseline and at regular time intervals during the study. Both the placebo- and thymopentin-treated groups demonstrated a progressive and statistically significant (p less than 0.001) decline in the overall severity of their disease, but reduction in the clinical severity score was higher in the thymopentin-treated group and statistically significant (p = 0.04) in comparison with the placebo-treated group after 6 weeks of treatment. Of the individual symptoms comprising the total severity score, pruritus (p = 0.02) and erythema (p = 0.04) were reduced significantly when thymopentin therapy was compared to placebo therapy. In addition, both the extent of body involvement and severity index (a combined severity/extent index) were significantly reduced after 6 weeks in the thymopentin-treated group in comparison to the placebo-treated group (p = 0.04). There were no serious adverse experiences in either treatment group. We conclude that treatment with thymopentin is safe and offers significant therapeutic promise for atopic dermatitis.
D Y Leung, and
R L Hirsch, and
L Schneider, and
C Moody, and
R Takaoka, and
S H Li, and
L A Meyerson, and
S G Mariam, and
G Goldstein, and
J M Hanifin
November 1998,
Clinical and experimental dermatology,
D Y Leung, and
R L Hirsch, and
L Schneider, and
C Moody, and
R Takaoka, and
S H Li, and
L A Meyerson, and
S G Mariam, and
G Goldstein, and
J M Hanifin
September 1992,
Archives of disease in childhood,
D Y Leung, and
R L Hirsch, and
L Schneider, and
C Moody, and
R Takaoka, and
S H Li, and
L A Meyerson, and
S G Mariam, and
G Goldstein, and
J M Hanifin
January 1989,
Acta dermato-venereologica. Supplementum,
D Y Leung, and
R L Hirsch, and
L Schneider, and
C Moody, and
R Takaoka, and
S H Li, and
L A Meyerson, and
S G Mariam, and
G Goldstein, and
J M Hanifin
May 1986,
Krankenpflege Journal,
D Y Leung, and
R L Hirsch, and
L Schneider, and
C Moody, and
R Takaoka, and
S H Li, and
L A Meyerson, and
S G Mariam, and
G Goldstein, and
J M Hanifin
January 2010,
Medicinski arhiv,
D Y Leung, and
R L Hirsch, and
L Schneider, and
C Moody, and
R Takaoka, and
S H Li, and
L A Meyerson, and
S G Mariam, and
G Goldstein, and
J M Hanifin
January 2018,
Clinics in dermatology,
D Y Leung, and
R L Hirsch, and
L Schneider, and
C Moody, and
R Takaoka, and
S H Li, and
L A Meyerson, and
S G Mariam, and
G Goldstein, and
J M Hanifin
November 1994,
The British journal of dermatology,
D Y Leung, and
R L Hirsch, and
L Schneider, and
C Moody, and
R Takaoka, and
S H Li, and
L A Meyerson, and
S G Mariam, and
G Goldstein, and
J M Hanifin
April 1996,
The British journal of dermatology,
D Y Leung, and
R L Hirsch, and
L Schneider, and
C Moody, and
R Takaoka, and
S H Li, and
L A Meyerson, and
S G Mariam, and
G Goldstein, and
J M Hanifin
August 1992,
Medizinische Monatsschrift fur Pharmazeuten,
D Y Leung, and
R L Hirsch, and
L Schneider, and
C Moody, and
R Takaoka, and
S H Li, and
L A Meyerson, and
S G Mariam, and
G Goldstein, and
J M Hanifin
June 2024,
Journal of the European Academy of Dermatology and Venereology : JEADV,
