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The effect of the type I interferon on the development and process of experimental pyelonephritis caused by E. coli was studied on mice weighing 12 to 14 g. Interferon was administered intraperitoneally in a dose of 1000 units on days 3 and 7 of the disease. It was shown that the administration of the type I interferon to the mice with experimental pyelonephritis promoted rapid elimination of bacteria from the kidneys, prevented their penetration to the contralateral (intact) kidney, prevented marked macro- and microscopic damages in the kidneys, lowered the intensity of the inflammatory reaction, and increased the phagocytic activity of neutrophils and the number of the E-rosette-forming lymphocytes in the thymus. The data provided experimental grounding for clinical trials of interferon preparations in treatment of bacterial pyelonephritis.
A V Rudenko, and
V G Maĭdannik, and
V A Pavlenko, and
N Ia Spivak, and
A M Romanenko, and
E M Ishchenko, and
L P Glebova, and
E N Bavina
August 1971,
Clinical science,
A V Rudenko, and
V G Maĭdannik, and
V A Pavlenko, and
N Ia Spivak, and
A M Romanenko, and
E M Ishchenko, and
L P Glebova, and
E N Bavina
October 1964,
Casopis lekaru ceskych,
A V Rudenko, and
V G Maĭdannik, and
V A Pavlenko, and
N Ia Spivak, and
A M Romanenko, and
E M Ishchenko, and
L P Glebova, and
E N Bavina
September 1972,
Infection and immunity,
A V Rudenko, and
V G Maĭdannik, and
V A Pavlenko, and
N Ia Spivak, and
A M Romanenko, and
E M Ishchenko, and
L P Glebova, and
E N Bavina
February 1992,
Biochemistry international,
A V Rudenko, and
V G Maĭdannik, and
V A Pavlenko, and
N Ia Spivak, and
A M Romanenko, and
E M Ishchenko, and
L P Glebova, and
E N Bavina
April 1988,
Zeitschrift fur Urologie und Nephrologie,
A V Rudenko, and
V G Maĭdannik, and
V A Pavlenko, and
N Ia Spivak, and
A M Romanenko, and
E M Ishchenko, and
L P Glebova, and
E N Bavina
January 1979,
Arzneimittel-Forschung,
A V Rudenko, and
V G Maĭdannik, and
V A Pavlenko, and
N Ia Spivak, and
A M Romanenko, and
E M Ishchenko, and
L P Glebova, and
E N Bavina
December 1968,
Casopis lekaru ceskych,
A V Rudenko, and
V G Maĭdannik, and
V A Pavlenko, and
N Ia Spivak, and
A M Romanenko, and
E M Ishchenko, and
L P Glebova, and
E N Bavina
January 1973,
Urologia internationalis,
A V Rudenko, and
V G Maĭdannik, and
V A Pavlenko, and
N Ia Spivak, and
A M Romanenko, and
E M Ishchenko, and
L P Glebova, and
E N Bavina
October 1969,
Arzneimittel-Forschung,
A V Rudenko, and
V G Maĭdannik, and
V A Pavlenko, and
N Ia Spivak, and
A M Romanenko, and
E M Ishchenko, and
L P Glebova, and
E N Bavina
March 1965,
Virchows Archiv fur pathologische Anatomie und Physiologie und fur klinische Medizin,
