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A crude preparation of 2-phenyladenosine was found to be mutagenic in the Ames Salmonella assay. In the purification of this preparation, it was revealed that 2-phenyladenosine itself was nonmutagenic but that 2-(m- and p-nitrophenyl)-adenosines (5m,p) contaminating the sample were the mutagenic principles. A structure-activity relationship study was carried out, and it was found that 5p, 2-(p-nitrophenyl)-adenine (7p), and 2-(p-nitrophenyl)-2'-deoxyadenosine (15p) were strongly mutagenic toward S. typhimurium TA98 and TA100 without metabolic activation, the potency being in the order 15p greater than 7p greater than 5p. The potency of 15p in TA98 was one order of magnitude greater than that of 4-nitroquinoline N-oxide. 15p also showed mutagenicity in the mouse cell line FM3A in culture.
A Matsuda, and
Y Ohara, and
T Kakutani, and
K Negishi, and
Y Wataya, and
H Hayatsu, and
T Ueda
January 1998,
Acta biochimica Polonica,
A Matsuda, and
Y Ohara, and
T Kakutani, and
K Negishi, and
Y Wataya, and
H Hayatsu, and
T Ueda
November 1964,
Nature,
A Matsuda, and
Y Ohara, and
T Kakutani, and
K Negishi, and
Y Wataya, and
H Hayatsu, and
T Ueda
January 2004,
Nucleosides, nucleotides & nucleic acids,
A Matsuda, and
Y Ohara, and
T Kakutani, and
K Negishi, and
Y Wataya, and
H Hayatsu, and
T Ueda
November 1967,
Biochemical and biophysical research communications,
A Matsuda, and
Y Ohara, and
T Kakutani, and
K Negishi, and
Y Wataya, and
H Hayatsu, and
T Ueda
June 2016,
The journal of physical chemistry. B,
A Matsuda, and
Y Ohara, and
T Kakutani, and
K Negishi, and
Y Wataya, and
H Hayatsu, and
T Ueda
May 2011,
Nucleosides, nucleotides & nucleic acids,
A Matsuda, and
Y Ohara, and
T Kakutani, and
K Negishi, and
Y Wataya, and
H Hayatsu, and
T Ueda
December 1983,
Carbohydrate research,
A Matsuda, and
Y Ohara, and
T Kakutani, and
K Negishi, and
Y Wataya, and
H Hayatsu, and
T Ueda
April 1948,
Pharmazeutische Zentralhalle fur Deutschland,
A Matsuda, and
Y Ohara, and
T Kakutani, and
K Negishi, and
Y Wataya, and
H Hayatsu, and
T Ueda
June 2004,
Acta crystallographica. Section C, Crystal structure communications,
A Matsuda, and
Y Ohara, and
T Kakutani, and
K Negishi, and
Y Wataya, and
H Hayatsu, and
T Ueda
January 1987,
Cancer chemotherapy and pharmacology,
