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Palate hyperpigmentation caused by prolonged use of the anti-malarial chloroquine. 2012
Mário Rodrigues de Melo Filho, and
Célsia Adriane Dias da Silva, and
Maurício da Rocha Dourado, and
Maria Betânia de Oliveira Pires, and
Sabina Pena Borges Pêgo, and
Edmilson Martins de Freitas
Department of Dentistry, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil.
The side-effects of many drugs manifest in the oral mucosa. The anti-malarial agent chloroquine diphosphate, which is also used to treat immunological, dermatological, and rheumatological disorders, usually causes pigmentary changes in the oral mucosa. This report presents a case of palate pigmentation related to the prolonged use of chloroquine diphosphate caused by the deposition of drug metabolites in the mucosa. Healthcare professionals must be aware of these drugs and their adverse effects in order to make the correct diagnosis, decide on the optimal treatment for the condition, or refer the patient to an appropriate specialist.
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