Biomaterial Database

Wernicke's encephalopathy manifested as Korsakoff's syndrome in a patient with promyelocytic leukemia. 1990

J E Pittella, and L P de Castro

Department of Pathology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.

A case of Wernicke's encephalopathy associated with promyelocytic leukemia found at autopsy is reported. The patient was 30 years old and was undergoing chemotherapeutic treatment when she had a memory deficit for recent events (Korsakoff's syndrome) which persisted for 6 months, until death. The neuropathologic examination showed typical, old lesions that characterize Wernicke's encephalopathy, but only in the mamillary bodies. This case is compared with three other cases of Wernicke's encephalopathy associated with leukemia previously described in the literature. Comment is made on the cliniconeuropathologic picture and risk factors in leukemic patients that may favor the appearance of Wernicke's encephalopathy.

UI	MeSH Term	Description	Entries
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D003937	Diagnosis, Differential	Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures.	Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000425	Alcohol Amnestic Disorder	A mental disorder associated with chronic ethanol abuse (ALCOHOLISM) and nutritional deficiencies characterized by short term memory loss, confabulations, and disturbances of attention. (Adams et al., Principles of Neurology, 6th ed, p1139)	Alcohol-Induced Amnestic Syndrome,Amnestic Psychosis, Alcohol-Induced,Alcohol Amnestic Syndrome,Alcohol-Induced Amnestic Psychosis,Alcohol-Induced Dysmnesic Psychosis,Alcohol-Induced Dysmnesic Syndrome,Alcohol-Induced Persisting Amnestic Disorder,Alcohol Amnestic Disorders,Alcohol Amnestic Syndromes,Alcohol Induced Amnestic Psychosis,Alcohol Induced Amnestic Syndrome,Alcohol Induced Dysmnesic Psychosis,Alcohol Induced Dysmnesic Syndrome,Alcohol Induced Persisting Amnestic Disorder,Alcohol-Induced Amnestic Psychoses,Alcohol-Induced Amnestic Syndromes,Alcohol-Induced Dysmnesic Psychoses,Alcohol-Induced Dysmnesic Syndromes,Amnestic Disorder, Alcohol,Amnestic Psychoses, Alcohol-Induced,Amnestic Psychosis, Alcohol Induced,Amnestic Syndrome, Alcohol-Induced,Amnestic Syndromes, Alcohol-Induced,Dysmnesic Psychoses, Alcohol-Induced,Dysmnesic Psychosis, Alcohol-Induced,Dysmnesic Syndrome, Alcohol-Induced,Dysmnesic Syndromes, Alcohol-Induced,Psychoses, Alcohol-Induced Amnestic,Psychoses, Alcohol-Induced Dysmnesic,Psychosis, Alcohol-Induced Amnestic,Psychosis, Alcohol-Induced Dysmnesic
D014899	Wernicke Encephalopathy	An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)	Beriberi, Cerebral,Encephalopathy, Wernicke,Encephalopathy, Gayet-Wernicke,Encephalopathy, Wernicke's,Gayet-Wernicke Encephalopathy,Wernicke Disease,Wernicke Polioencephalitis, Superior Hemorrhagic,Wernicke Superior Hemorrhagic Polioencephalitis,Wernicke Syndrome,Wernicke's Disease,Wernicke's Encephalopathy,Wernicke's Polioencephalitis, Superior Hemorrhagic,Wernicke's Superior Hemorrhagic Polioencephalitis,Wernicke's Syndrome,Cerebral Beriberi,Encephalopathies, Wernicke,Encephalopathy, Gayet Wernicke,Encephalopathy, Wernickes,Gayet Wernicke Encephalopathy,Wernicke Encephalopathies
D015473	Leukemia, Promyelocytic, Acute	An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.	Leukemia, Myeloid, Acute, M3,Leukemia, Progranulocytic,Myeloid Leukemia, Acute, M3,Progranulocytic Leukemia,Promyelocytic Leukemia, Acute,AML M3,Acute Promyelocytic Leukemia,Leukemia, Acute Promyelocytic,M3 ANLL,ANLL, M3,Acute Promyelocytic Leukemias