BIOMAT Database Logo BIOMAT Database Logo

Former smoking is a risk factor for chronic kidney disease after lung transplantation. 2011

M E Hellemons, and P K Agarwal, and W van der Bij, and E A M Verschuuren, and D Postmus, and M E Erasmus, and G J Navis, and S J L Bakker
Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands. m.e.hellemons@umcg.nl

Chronic kidney disease (CKD) is a common complication after lung transplantation (LTx). Smoking is a risk factor for many diseases, including CKD. Smoking cessation for >6 months is required for LTx enlistment. However, the impact of smoking history on CKD development after LTx remains unclear. We investigated the effect of former smoking on CKD and mortality after LTx. CKD was based on glomerular filtration rate (GFR) ((125) I-iothalamate measurements). GFR was measured before and repeatedly after LTx. One hundred thirty-four patients never smoked and 192 patients previously smoked for a median of 17.5 pack years. At 5 years after LTx, overall cumulative incidences of CKD-III, CKD-IV and death were 68.5%, 16.3% and 34.6%, respectively. Compared to never smokers, former smokers had a higher risk for CKD-III (hazard ratio [HR] 95% confidence interval [95%CI]= 1.69 [1.27-2.24]) and IV (HR = 1.90 [1.11-3.27]), but not for mortality (HR = 0.99 [0.71-1.38]). Adjustment for potential confounders did not change results. Thus, despite cessation, smoking history remained a risk factor for CKD in LTx recipients. Considering the increasing acceptance for LTx of older recipients with lower baseline renal function and an extensive smoking history, our data suggest that the problem of post-LTx CKD may increase in the future.

UI MeSH Term Description Entries
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D005919 Glomerular Filtration Rate The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance. Filtration Rate, Glomerular,Filtration Rates, Glomerular,Glomerular Filtration Rates,Rate, Glomerular Filtration,Rates, Glomerular Filtration
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012907 Smoking Willful or deliberate act of inhaling and exhaling SMOKE from burning substances or agents held by hand. Smoking Behaviors,Smoking Habit,Behavior, Smoking,Behaviors, Smoking,Habit, Smoking,Habits, Smoking,Smoking Behavior,Smoking Habits
D016040 Lung Transplantation The transference of either one or both of the lungs from one human or animal to another. Grafting, Lung,Transplantation, Lung,Graftings, Lung,Lung Grafting,Lung Graftings,Lung Transplantations,Transplantations, Lung
D016540 Smoking Cessation Discontinuing the habit of SMOKING. Giving Up Smoking,Quitting Smoking,Stopping Smoking,Cessation, Smoking,Smoking Cessations,Smoking, Giving Up,Smoking, Quitting,Smoking, Stopping,Smokings, Giving Up,Up Smoking, Giving

Related Publications

M E Hellemons, and P K Agarwal, and W van der Bij, and E A M Verschuuren, and D Postmus, and M E Erasmus, and G J Navis, and S J L Bakker
Polycystic kidney disease is a risk factor for new-onset diabetes after transplantation.
January 2007, Transplantation,
M E Hellemons, and P K Agarwal, and W van der Bij, and E A M Verschuuren, and D Postmus, and M E Erasmus, and G J Navis, and S J L Bakker
Smoking as risk factor for chronic kidney disease: systematic review.
January 2014, Jornal brasileiro de nefrologia,
M E Hellemons, and P K Agarwal, and W van der Bij, and E A M Verschuuren, and D Postmus, and M E Erasmus, and G J Navis, and S J L Bakker
Chronic Kidney Disease is a Risk Factor for Stroke.
September 2021, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association,
M E Hellemons, and P K Agarwal, and W van der Bij, and E A M Verschuuren, and D Postmus, and M E Erasmus, and G J Navis, and S J L Bakker
Chronic kidney disease after lung transplantation: incidence, risk factors, and treatment.
October 2010, Transplantation proceedings,
M E Hellemons, and P K Agarwal, and W van der Bij, and E A M Verschuuren, and D Postmus, and M E Erasmus, and G J Navis, and S J L Bakker
Kidney Transplantation in Patients With Chronic Kidney Disease After a Previous Lung Transplantation.
March 2019, Transplantation proceedings,
M E Hellemons, and P K Agarwal, and W van der Bij, and E A M Verschuuren, and D Postmus, and M E Erasmus, and G J Navis, and S J L Bakker
Is chronic kidney disease a cardiovascular disease risk factor?
January 2003, Seminars in dialysis,
M E Hellemons, and P K Agarwal, and W van der Bij, and E A M Verschuuren, and D Postmus, and M E Erasmus, and G J Navis, and S J L Bakker
Progressive chronic kidney disease after pediatric lung transplantation.
July 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
M E Hellemons, and P K Agarwal, and W van der Bij, and E A M Verschuuren, and D Postmus, and M E Erasmus, and G J Navis, and S J L Bakker
Chronic kidney disease: Psoriasis--a risk factor for chronic kidney disease?
January 2014, Nature reviews. Nephrology,
M E Hellemons, and P K Agarwal, and W van der Bij, and E A M Verschuuren, and D Postmus, and M E Erasmus, and G J Navis, and S J L Bakker
Diabetes is a major risk factor for mortality after lung transplantation.
February 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
M E Hellemons, and P K Agarwal, and W van der Bij, and E A M Verschuuren, and D Postmus, and M E Erasmus, and G J Navis, and S J L Bakker
Hyperlipidemia is associated with accelerated chronic kidney disease progression after lung transplantation.
November 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
Copied contents to your clipboard!