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The efficacy of constant-flow ventilation (CFV) was investigated in dogs with normal heart function (control phase, n = 8) and after development of left ventricular failure (LVF phase, n = 8). Heated, humidified and oxygen-enriched air (inspired oxygen fraction (Fio2) = 0.4) was continuously delivered via two catheters positioned within each mainstem bronchus at two flow rates (1.2 and 1.6 l/kg/min). Conventional mechanical ventilation (CMV) with positive end-expiratory pressure (PEEP) of 0.5 kPa was used as reference ventilation. During control, neither CMV with PEEP nor CFV revealed severe impairment of cardiopulmonary performance. Alveolo-arterial PO2 difference (P(A-a)O2) increased significantly during CFV1.2 and CFV1.6, indicating a higher degree of ventilation-perfusion (VA/Q) inhomogeneity. Acute left ventricular failure (LVF) was induced by proximal occlusion of the left anterior descending (LAD) coronary artery. Cardiac output (CO), maximum velocity of pressure development (dP/dtmax) and mixed venous PO2 decreased (P less than or equal to 0.05), whereas left ventricular end-diastolic pressure (LVEDP) and pulmonary capillary wedge pressure (PCWP) increased (P less than or equal to 0.05). Extravascular lung water (EVLW), as determined by thermal-dye technique, increased from 10.1 ml/kg to 20.9 ml/kg (P less than or equal to 0.01). Oxygenation, but not CO2 elimination, deteriorated in the LVF phase. There were no haemodynamic differences between CMV with PEEP and CFV1.2, but cardiopulmonary performance deteriorated with CFV1.6. Gas exchange was significantly more impaired during CFV1.2 and CFV1.6 due to increased VA/Q mismatching. However, there were no significant differences for P(A-a)O2 values between CFVControl and CFVLVF.(ABSTRACT TRUNCATED AT 250 WORDS)
T Hachenberg, and
J Meyer, and
A Sielenkämper, and
G Knichwitz, and
H Haberecht, and
H Gülker, and
M Wendt
March 1987,
Journal of applied physiology (Bethesda, Md. : 1985),
T Hachenberg, and
J Meyer, and
A Sielenkämper, and
G Knichwitz, and
H Haberecht, and
H Gülker, and
M Wendt
April 1986,
American heart journal,
T Hachenberg, and
J Meyer, and
A Sielenkämper, and
G Knichwitz, and
H Haberecht, and
H Gülker, and
M Wendt
February 1987,
Journal of applied physiology (Bethesda, Md. : 1985),
T Hachenberg, and
J Meyer, and
A Sielenkämper, and
G Knichwitz, and
H Haberecht, and
H Gülker, and
M Wendt
August 1987,
The American review of respiratory disease,
T Hachenberg, and
J Meyer, and
A Sielenkämper, and
G Knichwitz, and
H Haberecht, and
H Gülker, and
M Wendt
April 1996,
The Annals of thoracic surgery,
T Hachenberg, and
J Meyer, and
A Sielenkämper, and
G Knichwitz, and
H Haberecht, and
H Gülker, and
M Wendt
July 1991,
The Annals of thoracic surgery,
T Hachenberg, and
J Meyer, and
A Sielenkämper, and
G Knichwitz, and
H Haberecht, and
H Gülker, and
M Wendt
January 1966,
Transactions - American Society for Artificial Internal Organs,
T Hachenberg, and
J Meyer, and
A Sielenkämper, and
G Knichwitz, and
H Haberecht, and
H Gülker, and
M Wendt
December 1986,
Journal of applied physiology (Bethesda, Md. : 1985),
T Hachenberg, and
J Meyer, and
A Sielenkämper, and
G Knichwitz, and
H Haberecht, and
H Gülker, and
M Wendt
December 1991,
IEEE transactions on bio-medical engineering,
T Hachenberg, and
J Meyer, and
A Sielenkämper, and
G Knichwitz, and
H Haberecht, and
H Gülker, and
M Wendt
May 1988,
Journal of applied physiology (Bethesda, Md. : 1985),
