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Post transfusion purpura in a DR3, DRw52 positive, PlA1 negative woman rapidly responded to high-dose intravenous gammaglobulin therapy. Using the platelet immunofluorescence test (PIFT) high titre IgG and IgM alloantibodies were detected in the patient's acute serum. These alloantibodies had PlA1 specificity and the patient's serum produced a broad, 100 kDa band on Western Blot with PlA1 positive platelets. Acute phase serum also contained an IgG antibody which reacted in the PIFT with the patient's own platelets, and PlA1 negative platelets. When tested by Western Blot with PlA1 negative and Glanzmann's Thrombasthenia platelets, the acute serum produced bands at 180 and 200 kDa. The autoreactive antibody was not detected once the platelet count returned to normal. These findings provide evidence for the hypothesis that the mechanism of autologous platelet destruction in PTP is autoimmune.
R M Minchinton, and
I Cunningham, and
M Cole-Sinclair, and
M Van der Weyden, and
S Vaughan, and
K M McGrath
February 1975,
British medical journal,
R M Minchinton, and
I Cunningham, and
M Cole-Sinclair, and
M Van der Weyden, and
S Vaughan, and
K M McGrath
January 1999,
Vox sanguinis,
R M Minchinton, and
I Cunningham, and
M Cole-Sinclair, and
M Van der Weyden, and
S Vaughan, and
K M McGrath
January 1967,
Danish medical bulletin,
R M Minchinton, and
I Cunningham, and
M Cole-Sinclair, and
M Van der Weyden, and
S Vaughan, and
K M McGrath
March 2005,
Current hematology reports,
R M Minchinton, and
I Cunningham, and
M Cole-Sinclair, and
M Van der Weyden, and
S Vaughan, and
K M McGrath
August 1966,
The New England journal of medicine,
R M Minchinton, and
I Cunningham, and
M Cole-Sinclair, and
M Van der Weyden, and
S Vaughan, and
K M McGrath
November 1986,
British journal of haematology,
R M Minchinton, and
I Cunningham, and
M Cole-Sinclair, and
M Van der Weyden, and
S Vaughan, and
K M McGrath
May 1980,
The Medical journal of Australia,
R M Minchinton, and
I Cunningham, and
M Cole-Sinclair, and
M Van der Weyden, and
S Vaughan, and
K M McGrath
November 1976,
The Nebraska medical journal,
R M Minchinton, and
I Cunningham, and
M Cole-Sinclair, and
M Van der Weyden, and
S Vaughan, and
K M McGrath
January 1991,
The Journal of the American Board of Family Practice,
R M Minchinton, and
I Cunningham, and
M Cole-Sinclair, and
M Van der Weyden, and
S Vaughan, and
K M McGrath
January 1977,
Nihon rinsho. Japanese journal of clinical medicine,
