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Effects of gastrodia elata bl on phencyclidine-induced schizophrenia-like psychosis in mice. 2011

E-J Shin, and J-M Kim, and X-K T Nguyen, and T-T L Nguyen, and S Y Lee, and J-H Jung, and M J Kim, and W K Whang, and K Yamada, and T Nabeshima, and H-C Kim
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, South Korea.

It has been demonstrated that 5-HT(1A) receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT(1A) receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT(1A) receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT(1A) in mice.

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