[Allergic bronchopulmonary mycosis due to Schizophyllum commune and Aspergillus fumigatus]. 2011

Takashi Ishiguro, and Noboru Takayanagi, and Akemi Saito, and Kazuo Akiyama, and Megumi Wakayama, and Kazutoshi Shibuya, and Yoshihiko Shimizu, and Yutaka Sugita, and Katsuhiko Kamei
Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center.

A 53-year-old man who had been suffering from asthma presented to our hospital because of abnormal shadows detected on a chest X-ray film during a routine medical examination. A biopsy specimen of a mucus plug obtained by bronchoscopy showed fungal hyphae, eosinophils, and Charcot-Leyden crystals, with evidence of lung tissue eosinophilia. Schizophyllum commune and Aspergillus fumigatus were isolated from his sputum, bronchial washing specimens and the mucus plug. We detected specific immunoglobulin E anti-Aspergillus fumigatus responses and precipitating antibodies against Schizophyllum commune and Aspergillus fumigatus, which led to the diagnosis of allergic bronchopulmonary mycosis caused by both fungi. We gave him fluticasone/salmeterol and itraconazole; thereafter, his symptoms of cough and sputum production and his radiological findings all improved.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001229 Aspergillosis, Allergic Bronchopulmonary Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen. Allergic Bronchopulmonary Aspergillosis,Allergic Bronchopulmonary Aspergilloses,Aspergilloses, Allergic Bronchopulmonary,Aspergillosis, Bronchopulmonary Allergic,Bronchopulmonary Aspergilloses, Allergic,Bronchopulmonary Aspergillosis, Allergic,Allergic Aspergilloses, Bronchopulmonary,Allergic Aspergillosis, Bronchopulmonary,Aspergilloses, Bronchopulmonary Allergic,Bronchopulmonary Allergic Aspergilloses,Bronchopulmonary Allergic Aspergillosis
D001232 Aspergillus fumigatus A species of imperfect fungi from which the antibiotic fumigatin is obtained. Its spores may cause respiratory infection in birds and mammals. Aspergillus fumigates,Neosartorya fumigata,Sartorya fumigata
D012567 Schizophyllum A genus of fleshy shelf basidiomycetous fungi, family Schizophyllaceae, order AGARICALES, growing on woody substrata. It is pathogenic in humans. Schizophyllum commune,Schizophyllums
D055744 Invasive Pulmonary Aspergillosis Lung infections with the invasive forms of ASPERGILLUS, usually after surgery, transplantation, prolonged NEUTROPENIA or treatment with high-doses of CORTICOSTEROIDS. Invasive pulmonary aspergillosis can progress to CHRONIC NECROTIZING PULMONARY ASPERGILLOSIS or hematogenous spread to other organs. Allergic Bronchopulmonary Mycosis,Chronic Necrotizing Pulmonary Aspergillosis,Pulmonary Aspergillosis - Invasive,Allergic Bronchopulmonary Mycoses,Aspergillosis, Invasive Pulmonary,Bronchopulmonary Mycoses, Allergic,Bronchopulmonary Mycosis, Allergic,Mycoses, Allergic Bronchopulmonary,Mycosis, Allergic Bronchopulmonary,Pulmonary Aspergilloses, Invasive,Pulmonary Aspergillosis Invasive,Pulmonary Aspergillosis, Invasive

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