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Urinary 6beta-hydroxycortisol (6betaOHF) excretion was measured and compared with free cortisol and 17-hydroxycorticosteroid (17OH) excretion in normal children, patients with Cushing's syndrome or disease (CSD), and patients during cortisol therapy. Normal 6betaOHF excretion in children was 0.23 +/- 0.03 mg/m2/24 h (mean +/- SE). No sex difference was found. ACTH infusion (40 U/day for 5 days) and high dose cortisol altered the 6 betaOHF:17OH ratio so that it was indistinguishable from the ratio seen in CSD. The fact that both Cushing's disease and high dose cortisol therapy caused the same change in the 6 betaOHF:17OH ratio suggests that cortisol and not ACTH induced 6beta-hydroxylase in hypercortisolemic subjects. Since the 6betaOHF:17OH ratio in CSD patients was always well above the normal range, measurement of 6betaOHF excretion was a better and more rapid test for chronic hypercortisolemia than urinary 17OH or free cortisol. Thus, measurement of urinary 6betaOHF is suggested as a good diagnostic test for hypercortisolemic states.
E Voccia, and
P Saenger, and
R E Peterson, and
W Rauh, and
K Gottesdiener, and
L S Levine, and
M I New
September 1982,
Journal of steroid biochemistry,
E Voccia, and
P Saenger, and
R E Peterson, and
W Rauh, and
K Gottesdiener, and
L S Levine, and
M I New
June 1969,
The Journal of clinical endocrinology and metabolism,
E Voccia, and
P Saenger, and
R E Peterson, and
W Rauh, and
K Gottesdiener, and
L S Levine, and
M I New
January 1997,
British journal of rheumatology,
E Voccia, and
P Saenger, and
R E Peterson, and
W Rauh, and
K Gottesdiener, and
L S Levine, and
M I New
February 1984,
The Journal of clinical endocrinology and metabolism,
E Voccia, and
P Saenger, and
R E Peterson, and
W Rauh, and
K Gottesdiener, and
L S Levine, and
M I New
March 1995,
Nihon rinsho. Japanese journal of clinical medicine,
E Voccia, and
P Saenger, and
R E Peterson, and
W Rauh, and
K Gottesdiener, and
L S Levine, and
M I New
August 1967,
Horumon to rinsho. Clinical endocrinology,
E Voccia, and
P Saenger, and
R E Peterson, and
W Rauh, and
K Gottesdiener, and
L S Levine, and
M I New
May 1998,
Clinical and experimental pharmacology & physiology,
E Voccia, and
P Saenger, and
R E Peterson, and
W Rauh, and
K Gottesdiener, and
L S Levine, and
M I New
May 1982,
British journal of clinical pharmacology,
E Voccia, and
P Saenger, and
R E Peterson, and
W Rauh, and
K Gottesdiener, and
L S Levine, and
M I New
December 1999,
Nihon rinsho. Japanese journal of clinical medicine,
E Voccia, and
P Saenger, and
R E Peterson, and
W Rauh, and
K Gottesdiener, and
L S Levine, and
M I New
April 1969,
Steroids,
