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OBJECTIVE Shiga-like toxins I and II (Stx1 and Stx2) play an important role in the pathogenesis of renal disease by causing renal microvascular injury. A murine model was used to study glomerular lesions produced by Stx1 and Stx2. METHODS Swiss albino mice of the Rockefeller strain were inoculated intraperitoneally with LD(50) doses of endotoxin-free Stx1 of Stx2 and observed for signs of disease. Samples of renal cortical tissue from mice were examined with the electron microscope. RESULTS the mice developed systemic and neurological symptoms including hind limb paralysis and generalised convulsions. Renal arteriolar damage and glomerular endothelial cytoplasmic swelling, vacuolation, lysis and intravascular coagulation were present and resembled the microangiopathy seen in renal biopsies from patients. CONCLUSIONS these experiments establish the role of Stx1 and Stx2 in glomerular vascular injury and provide a model for studying the pathogenesis of Shiga-like toxin related microangiopathy.
R Koshi, and
A B Pulimood, and
A Date, and
G Kang, and
D Acheson, and
M M Mathan
January 1990,
Revista de igiena, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Bacteriologia, virusologia, parazitologia, epidemiologia,
R Koshi, and
A B Pulimood, and
A Date, and
G Kang, and
D Acheson, and
M M Mathan
June 1987,
Microbiological reviews,
R Koshi, and
A B Pulimood, and
A Date, and
G Kang, and
D Acheson, and
M M Mathan
January 1998,
Kidney & blood pressure research,
R Koshi, and
A B Pulimood, and
A Date, and
G Kang, and
D Acheson, and
M M Mathan
March 1995,
The Journal of infectious diseases,
R Koshi, and
A B Pulimood, and
A Date, and
G Kang, and
D Acheson, and
M M Mathan
February 1986,
The American journal of pathology,
R Koshi, and
A B Pulimood, and
A Date, and
G Kang, and
D Acheson, and
M M Mathan
June 1976,
Journal of radiation research,
R Koshi, and
A B Pulimood, and
A Date, and
G Kang, and
D Acheson, and
M M Mathan
June 1990,
Pain,
R Koshi, and
A B Pulimood, and
A Date, and
G Kang, and
D Acheson, and
M M Mathan
April 1990,
Microbial pathogenesis,
R Koshi, and
A B Pulimood, and
A Date, and
G Kang, and
D Acheson, and
M M Mathan
August 1991,
Molecular microbiology,
R Koshi, and
A B Pulimood, and
A Date, and
G Kang, and
D Acheson, and
M M Mathan
May 2001,
Microbes and infection,
