-transparent.png){kind=logo}
The pathogenesis of IgA nephropathy has remained elusive in the twenty years that have passed since the first description of the disease. Based on the recent literature, we present a pathogenetic model in which a primary disorder of immune regulation plays a central role. This disorder of immune regulation results in an increased synthesis of plasma IgAI antibodies by the bone marrow, in response to everyday mucosal infections. Through an unknown mechanism, these circulating IgAI antibodies deposit in the mesangium, and cause an inflammatory response.
Related Publications
A W van den Wall Bake, and
M R Daha, and
L A van Es
July 2011,
Seminars in nephrology,
A W van den Wall Bake, and
M R Daha, and
L A van Es
May 2003,
Springer seminars in immunopathology,
A W van den Wall Bake, and
M R Daha, and
L A van Es
March 2011,
Current opinion in nephrology and hypertension,
A W van den Wall Bake, and
M R Daha, and
L A van Es
January 1995,
Acta clinica Belgica,
A W van den Wall Bake, and
M R Daha, and
L A van Es
June 1992,
Kidney international,
A W van den Wall Bake, and
M R Daha, and
L A van Es
November 2003,
Seminars in nephrology,
A W van den Wall Bake, and
M R Daha, and
L A van Es
February 1999,
Annales de medecine interne,
A W van den Wall Bake, and
M R Daha, and
L A van Es
May 2004,
Seminars in nephrology,
A W van den Wall Bake, and
M R Daha, and
L A van Es
March 2012,
Nature reviews. Nephrology,
A W van den Wall Bake, and
M R Daha, and
L A van Es
January 2007,
Contributions to nephrology,
