-transparent.png){kind=logo}
The initiation sensitivity of the liver of the LEC (Long-Evans with a cinnamon-like coat color) rat, a new mutant strain with a high incidence of spontaneous liver tumors, was studied by treatment with low doses of diethylnitrosamine (DEN) coupled with modified Solt and Farber's selection. LEC and control LEA (Long-Evans with an agouti coat color) rats received i.p. injections of 10 mg/kg of DEN, then selected by feeding with a diet containing 0.02% 2-acetylaminofluorene (AAF) for 7 days combined with partial hepatectomy (PH). The numbers of placental glutathione S-transferase (GST-P)-positive foci in the livers of LEC rats were 10 times higher than those in LEA rats. These results suggested a high sensitivity of the LEC rat liver to the carcinogenic effect of DEN. The association between initiation sensitivity and spontaneous liver-tumor development and the possible usefulness of the LEC rat for in vivo short-term tests of hepatocarcinogens are discussed.
H Takahashi, and
K Enomoto, and
Y Nakajima, and
M Mori
February 1998,
Zhonghua bing li xue za zhi = Chinese journal of pathology,
H Takahashi, and
K Enomoto, and
Y Nakajima, and
M Mori
October 1963,
Arzneimittel-Forschung,
H Takahashi, and
K Enomoto, and
Y Nakajima, and
M Mori
January 1967,
Die Naturwissenschaften,
H Takahashi, and
K Enomoto, and
Y Nakajima, and
M Mori
January 1967,
Die Naturwissenschaften,
H Takahashi, and
K Enomoto, and
Y Nakajima, and
M Mori
March 2024,
International journal of biological macromolecules,
H Takahashi, and
K Enomoto, and
Y Nakajima, and
M Mori
April 2015,
Laboratory animals,
H Takahashi, and
K Enomoto, and
Y Nakajima, and
M Mori
April 1977,
Biulleten' eksperimental'noi biologii i meditsiny,
H Takahashi, and
K Enomoto, and
Y Nakajima, and
M Mori
January 1974,
Experimentelle Pathologie,
H Takahashi, and
K Enomoto, and
Y Nakajima, and
M Mori
October 1973,
Experientia,
H Takahashi, and
K Enomoto, and
Y Nakajima, and
M Mori
January 1989,
Japanese journal of pharmacology,
