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We review a unique case of NUT midline carcinoma that presented in a young girl with an initial diagnosis of tonsillar abscess. We stress the importance of assaying poorly differentiated carcinomas in young patients for the t(15;19) translocation. Our patient presented with tonsillar enlargement and cervical lymphadenopathy mimicking acute tonsillitis. The clinical suspicion for malignancy arose after an aspirate from the tonsil did not yield any pus, and biopsy of a cervical lymph node demonstrated undifferentiated carcinoma. Further analysis by fluorescence in situ hybridization was positive for rearrangements in both BRD4 and NUT genes consistent with NUT carcinoma. In addition, fluorodeoxyglucose-positron emission tomography (FDG-PET) revealed a very high standard uptake value in both the primary tumor and metastatic foci, suggesting that FDG-PET could be a useful tool in the staging and follow-up of NUT midline carcinoma.
Amy L Rutt, and
Janet Poulik, and
Abdul Hafeez Siddiqui, and
Andre Konski, and
Majid Kalaf, and
David N Madgy, and
Zhihong J Wang
January 2015,
Indian journal of dermatology, venereology and leprology,
Amy L Rutt, and
Janet Poulik, and
Abdul Hafeez Siddiqui, and
Andre Konski, and
Majid Kalaf, and
David N Madgy, and
Zhihong J Wang
November 1994,
Australian and New Zealand journal of ophthalmology,
Amy L Rutt, and
Janet Poulik, and
Abdul Hafeez Siddiqui, and
Andre Konski, and
Majid Kalaf, and
David N Madgy, and
Zhihong J Wang
February 2011,
American family physician,
Amy L Rutt, and
Janet Poulik, and
Abdul Hafeez Siddiqui, and
Andre Konski, and
Majid Kalaf, and
David N Madgy, and
Zhihong J Wang
January 1972,
Acta gastroenterologica Latinoamericana,
Amy L Rutt, and
Janet Poulik, and
Abdul Hafeez Siddiqui, and
Andre Konski, and
Majid Kalaf, and
David N Madgy, and
Zhihong J Wang
September 1960,
American journal of diseases of children (1960),
Amy L Rutt, and
Janet Poulik, and
Abdul Hafeez Siddiqui, and
Andre Konski, and
Majid Kalaf, and
David N Madgy, and
Zhihong J Wang
October 2018,
Archivos de bronconeumologia,
Amy L Rutt, and
Janet Poulik, and
Abdul Hafeez Siddiqui, and
Andre Konski, and
Majid Kalaf, and
David N Madgy, and
Zhihong J Wang
December 2017,
Fetal and pediatric pathology,
Amy L Rutt, and
Janet Poulik, and
Abdul Hafeez Siddiqui, and
Andre Konski, and
Majid Kalaf, and
David N Madgy, and
Zhihong J Wang
May 2022,
International journal of surgery case reports,
Amy L Rutt, and
Janet Poulik, and
Abdul Hafeez Siddiqui, and
Andre Konski, and
Majid Kalaf, and
David N Madgy, and
Zhihong J Wang
January 2004,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
Amy L Rutt, and
Janet Poulik, and
Abdul Hafeez Siddiqui, and
Andre Konski, and
Majid Kalaf, and
David N Madgy, and
Zhihong J Wang
September 2020,
Cureus,
