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Pregnant rats received whole body irradiation with 2.6 Gy gamma-ray from a 60Co source at Day 20 of gestation. When pups were 4 months old, activities of electron transport system and steroid monooxygenase in tests were assayed. The content of total cytochrome P-450 in the irradiated testes had increased to 170% of that in non-irradiated rats, but NADPH-cytochrome P-450 reductase activity had reduced to 36% of the control. Also, amounts of cytochrome b5 in testicular microsomal fraction were decreased markedly after irradiation, but no significant change of NADH-cytochrome b5 reductase activity was observed in the treated pups. Because both 17 alpha-hydroxylase and C17-C20 lyase activities tended to be decreased by fetal irradiation, testosterone production from progesterone and 17 alpha-hydroxyprogesterone was reduced to about 30% of the control. From these results, it has been suggested that the testicular cytochrome P-450 is radioresistant but steroid monooxygenase activities are reduced after the fetal irradiation. We propose that the discrepancy arises from the marked decrement of NADPH-cytochrome P-450 reductase activity.
H Inano, and
H Ishii-Ohba, and
K Suzuki, and
K Ikeda
December 1993,
The Journal of endocrinology,
H Inano, and
H Ishii-Ohba, and
K Suzuki, and
K Ikeda
December 1989,
Journal of steroid biochemistry,
H Inano, and
H Ishii-Ohba, and
K Suzuki, and
K Ikeda
July 1981,
Biochemistry,
H Inano, and
H Ishii-Ohba, and
K Suzuki, and
K Ikeda
September 1965,
Biochimica et biophysica acta,
H Inano, and
H Ishii-Ohba, and
K Suzuki, and
K Ikeda
January 1975,
Current topics in molecular endocrinology,
H Inano, and
H Ishii-Ohba, and
K Suzuki, and
K Ikeda
November 1988,
Analytical biochemistry,
H Inano, and
H Ishii-Ohba, and
K Suzuki, and
K Ikeda
December 1992,
The Journal of endocrinology,
H Inano, and
H Ishii-Ohba, and
K Suzuki, and
K Ikeda
November 1992,
Biochimica et biophysica acta,
H Inano, and
H Ishii-Ohba, and
K Suzuki, and
K Ikeda
September 1994,
The Journal of steroid biochemistry and molecular biology,
H Inano, and
H Ishii-Ohba, and
K Suzuki, and
K Ikeda
January 1996,
Biochemical and biophysical research communications,
