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OBJECTIVE To determine whether early development of carcinoma in young patients could be explained by an alternative pathway such as microsatellite instability or whether it follows the classical tumor suppressor pathway characterized by loss of heterozygosity. METHODS Microsatellite instability, loss of heterozygosity, and multiple mismatch repair, p16, p53, and p63 protein expression were analyzed in a series of 18 young patients with laryngeal cancer. RESULTS Only 2 of the 18 cases showed low microsatellite instability, whereas 9 of 17 presented loss of heterozygosity in at least one of the markers tested. All cases retained multiple mismatch repair protein expression. The p53, p16, and p63 expression profiles were consistent with the classical tumor suppressor pathway. CONCLUSIONS Laryngeal carcinoma in young patients develops through the classical tumor suppressor pathway.
Laura Conde, and
Susana Moyano, and
Isabel Vilaseca, and
Miguel Moragas, and
Antonio Cardesa, and
Alfons Nadal
March 1998,
Cancer genetics and cytogenetics,
Laura Conde, and
Susana Moyano, and
Isabel Vilaseca, and
Miguel Moragas, and
Antonio Cardesa, and
Alfons Nadal
January 2012,
Acta otorrinolaringologica espanola,
Laura Conde, and
Susana Moyano, and
Isabel Vilaseca, and
Miguel Moragas, and
Antonio Cardesa, and
Alfons Nadal
August 2001,
International journal of oncology,
Laura Conde, and
Susana Moyano, and
Isabel Vilaseca, and
Miguel Moragas, and
Antonio Cardesa, and
Alfons Nadal
August 1998,
Pathology international,
Laura Conde, and
Susana Moyano, and
Isabel Vilaseca, and
Miguel Moragas, and
Antonio Cardesa, and
Alfons Nadal
September 2002,
Annals of oncology : official journal of the European Society for Medical Oncology,
Laura Conde, and
Susana Moyano, and
Isabel Vilaseca, and
Miguel Moragas, and
Antonio Cardesa, and
Alfons Nadal
January 2011,
Hepato-gastroenterology,
Laura Conde, and
Susana Moyano, and
Isabel Vilaseca, and
Miguel Moragas, and
Antonio Cardesa, and
Alfons Nadal
June 2007,
The Journal of otolaryngology,
Laura Conde, and
Susana Moyano, and
Isabel Vilaseca, and
Miguel Moragas, and
Antonio Cardesa, and
Alfons Nadal
February 1998,
Gut,
Laura Conde, and
Susana Moyano, and
Isabel Vilaseca, and
Miguel Moragas, and
Antonio Cardesa, and
Alfons Nadal
April 2006,
European urology,
Laura Conde, and
Susana Moyano, and
Isabel Vilaseca, and
Miguel Moragas, and
Antonio Cardesa, and
Alfons Nadal
July 2020,
Hepatology research : the official journal of the Japan Society of Hepatology,
