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BACKGROUND Pneumonia is the most frequent nosocomial infection in intensive care units. The reported frequency varies with definition, the type of hospital or intensive care units and the population of patients. The incidence ranges from 6.8-27%. OBJECTIVE The objective of this study was to determine the frequency, risk factors and mortality of nosocomial pneumonia in intensive care patients. METHODS We analyzed retrospectively and prospectively the collected data of 180 patients with central nervous system infections who needed to stay in the intensive care unit for more than 48 hours. This study was conducted from 2003 to 2009 at the Clinical Centre of Kragujevac. RESULTS During the study period, 54 (30%) patients developed nosocomial pneumonia. The time to develop pneumonia was 10 +/-6 days. We found that the following risk factors for the development of nosocomial pneumonia were statistically significant: age, Glasgow Coma Scale (GCS) score < 9, mechanical ventilation, duration of mechanical ventilation, tracheostomy, presence of nasogastric tube and enteral feeding. The most commonly isolated pathogens were Klebsiella-Enterobacter spp. (33.3%), Pseudomonas aeruginosa (24.1%), Acinetobacter spp. (16.6%) and Staphylococcus aureus (25.9%). CONCLUSIONS Nosocomial pneumonia is the major cause of morbidity and mortality of patients with central nervous system infections. Patients on mechanical ventilation are particularly at a high risk. The mortality rate of patients with nosocomial pneumonia was 54.4% and it was five times higher than in patients without pneumonia.
Olgica Gajović, and
Zoran Todorović, and
Zeljko Mijalilović, and
Predrag Canović, and
Ljiljana Nešić, and
Zorana Djordjević, and
Marijana Stanojević, and
Zorica Lazić
January 2007,
Medicinski pregled,
Olgica Gajović, and
Zoran Todorović, and
Zeljko Mijalilović, and
Predrag Canović, and
Ljiljana Nešić, and
Zorana Djordjević, and
Marijana Stanojević, and
Zorica Lazić
December 2001,
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Olgica Gajović, and
Zoran Todorović, and
Zeljko Mijalilović, and
Predrag Canović, and
Ljiljana Nešić, and
Zorana Djordjević, and
Marijana Stanojević, and
Zorica Lazić
March 2024,
Hematological oncology,
Olgica Gajović, and
Zoran Todorović, and
Zeljko Mijalilović, and
Predrag Canović, and
Ljiljana Nešić, and
Zorana Djordjević, and
Marijana Stanojević, and
Zorica Lazić
September 1990,
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Olgica Gajović, and
Zoran Todorović, and
Zeljko Mijalilović, and
Predrag Canović, and
Ljiljana Nešić, and
Zorana Djordjević, and
Marijana Stanojević, and
Zorica Lazić
July 1991,
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Olgica Gajović, and
Zoran Todorović, and
Zeljko Mijalilović, and
Predrag Canović, and
Ljiljana Nešić, and
Zorana Djordjević, and
Marijana Stanojević, and
Zorica Lazić
April 2001,
The European respiratory journal,
Olgica Gajović, and
Zoran Todorović, and
Zeljko Mijalilović, and
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Ljiljana Nešić, and
Zorana Djordjević, and
Marijana Stanojević, and
Zorica Lazić
September 1999,
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Olgica Gajović, and
Zoran Todorović, and
Zeljko Mijalilović, and
Predrag Canović, and
Ljiljana Nešić, and
Zorana Djordjević, and
Marijana Stanojević, and
Zorica Lazić
May 1984,
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Olgica Gajović, and
Zoran Todorović, and
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Predrag Canović, and
Ljiljana Nešić, and
Zorana Djordjević, and
Marijana Stanojević, and
Zorica Lazić
January 2020,
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Olgica Gajović, and
Zoran Todorović, and
Zeljko Mijalilović, and
Predrag Canović, and
Ljiljana Nešić, and
Zorana Djordjević, and
Marijana Stanojević, and
Zorica Lazić
December 2005,
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