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Although myo-inositol hexakisphosphate (InsP6; phytate) is the most abundant inositol phosphate in nature and probably has a wide variety of functions, neither the route of its synthesis from myo-inositol nor its metabolic relationships with other inositol-containing compounds (such as the second messenger inositol 1,4,5-trisphosphate, Ins(1,4,5)P3) are known. Here we report that the pathway by which InsP6 is synthesized in the cellular slime mould Dictyostelium, and in cell-free preparations derived from them, is catalysed by a series of soluble ATP-dependent kinases independently of the metabolism of both phosphatidylinositol and Ins(1,4,5)P3. The intermediates between myo-inositol and InsP6 are Ins3P, Ins(3,6)P2, Ins(3,4,6)P3, Ins(1,3,4,6)P4 and Ins(1,3,4,5,6)P5. The 3- and 5-phosphates of InsP6 take part in futile cycles in which Ins(1,2,4,5,6)P5 and Ins(1,2,3,4,6)P5 are rapidly formed by dephosphorylation of InsP6, only to be rephosphorylated to yield their precursor.
L R Stephens, and
R F Irvine
November 2003,
Phytochemistry,
L R Stephens, and
R F Irvine
January 2016,
International journal of endocrinology,
L R Stephens, and
R F Irvine
June 1994,
Journal of bacteriology,
L R Stephens, and
R F Irvine
January 2006,
Frontiers in bioscience : a journal and virtual library,
L R Stephens, and
R F Irvine
January 2005,
Anticancer research,
L R Stephens, and
R F Irvine
June 2007,
International journal of food microbiology,
L R Stephens, and
R F Irvine
July 2006,
The FEBS journal,
L R Stephens, and
R F Irvine
July 2015,
Organic & biomolecular chemistry,
L R Stephens, and
R F Irvine
September 2021,
Biochemistry,
L R Stephens, and
R F Irvine
July 2006,
Die Pharmazie,
