[Exposure to nanoparticle-rich diesel exhaust affects hippocampal functions in mice]. 2011

Tin Tin Win-Shwe, and Yuji Fujitani, and Seishiro Hirano, and Hidekazu Fujimaki
Center for Environmental Risk Research, National Institute for Environmental Studies. Ibaraki, Japan. tin.tin.win.shwe@nies.go.jp

Epidemiological studies have indicated associations between day-to-day particulate air pollution and increased risks of various adverse health outcomes. Although an association between exposure to diesel exhaust particles (DEPs) and the development of pulmonary inflammation has been reported, there are limited reports on the neurotoxic effects of DEPs, particularly those of nanoparticle-rich diesel exhaust (NRDE). In this minireview, we highlighted the effects of NRDE which was generated in the National Institute for Environmental Studies, on hippocampus-dependent spatial learning ability and the expression of memory-function-related genes, neurotrophins, and proinflammatory cytokines in a mouse model.

UI MeSH Term Description Entries
D007858 Learning Relatively permanent change in behavior that is the result of past experience or practice. The concept includes the acquisition of knowledge. Phenomenography
D008297 Male Males
D008568 Memory Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001335 Vehicle Emissions Gases, fumes, vapors, and ODORANTS escaping from the cylinders of a gasoline or diesel internal-combustion engine. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Random House Unabridged Dictionary, 2d ed) Automobile Exhaust,Diesel Exhaust,Engine Exhaust,Vehicle Emission,Vehicular Emission,Traffic-Related Pollutants,Transportation Emissions,Vehicular Emissions,Emission, Vehicle,Emission, Vehicular,Emissions, Transportation,Emissions, Vehicle,Emissions, Vehicular,Exhaust, Automobile,Exhaust, Diesel,Exhaust, Engine,Pollutants, Traffic-Related,Traffic Related Pollutants
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D052638 Particulate Matter Particles of any solid substance, generally under 30 microns in size, often noted as PM30. There is special concern with PM1 which can get down to PULMONARY ALVEOLI and induce MACROPHAGE ACTIVATION and PHAGOCYTOSIS leading to FOREIGN BODY REACTION and LUNG DISEASES. Ultrafine Fiber,Ultrafine Fibers,Ultrafine Particle,Ultrafine Particles,Ultrafine Particulate Matter,Air Pollutants, Particulate,Airborne Particulate Matter,Ambient Particulate Matter,Fiber, Ultrafine,Particle, Ultrafine,Particles, Ultrafine,Particulate Air Pollutants,Particulate Matter, Airborne,Particulate Matter, Ambient,Particulate Matter, Ultrafine
D053758 Nanoparticles Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging. Nanocrystalline Materials,Nanocrystals,Material, Nanocrystalline,Materials, Nanocrystalline,Nanocrystal,Nanocrystalline Material,Nanoparticle

Related Publications

Tin Tin Win-Shwe, and Yuji Fujitani, and Seishiro Hirano, and Hidekazu Fujimaki
September 2011, Nihon eiseigaku zasshi. Japanese journal of hygiene,
Tin Tin Win-Shwe, and Yuji Fujitani, and Seishiro Hirano, and Hidekazu Fujimaki
March 2012, Toxicology letters,
Tin Tin Win-Shwe, and Yuji Fujitani, and Seishiro Hirano, and Hidekazu Fujimaki
January 2013, The Journal of reproduction and development,
Tin Tin Win-Shwe, and Yuji Fujitani, and Seishiro Hirano, and Hidekazu Fujimaki
October 1999, International journal of andrology,
Tin Tin Win-Shwe, and Yuji Fujitani, and Seishiro Hirano, and Hidekazu Fujimaki
January 2013, The Journal of toxicological sciences,
Tin Tin Win-Shwe, and Yuji Fujitani, and Seishiro Hirano, and Hidekazu Fujimaki
August 2012, Inhalation toxicology,
Tin Tin Win-Shwe, and Yuji Fujitani, and Seishiro Hirano, and Hidekazu Fujimaki
February 2009, Toxicology letters,
Tin Tin Win-Shwe, and Yuji Fujitani, and Seishiro Hirano, and Hidekazu Fujimaki
February 2013, The Journal of toxicological sciences,
Tin Tin Win-Shwe, and Yuji Fujitani, and Seishiro Hirano, and Hidekazu Fujimaki
September 2013, Experimental and therapeutic medicine,
Tin Tin Win-Shwe, and Yuji Fujitani, and Seishiro Hirano, and Hidekazu Fujimaki
February 2013, The Journal of toxicological sciences,
Copied contents to your clipboard!