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Isoptin and obsidan were demonstrated to cause a significant increase in exercise tolerance in patients with Stages I and II hypertensive disease. The response of blood pressure to isoptin and obsidan was virtually identical, yet isoptin acted longer. When obsidan was administered, there was a decrease in specific peripheral vascular resistance with a stepwise elevation of blood pressure, whereas isoptin promoted its slight rise with maximally elevated blood pressure. Isoptin administration prevented brain hyperperfusion at maximum blood pressures.
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