Vibration disease due to hand-held vibratory tools has various symptoms and signs which can be characterized by the severity. They include disorders of the central and autonomic nervous systems, as well as peripheral system disorders. The mechanism of Raynaud's phenomenon in vibration disease is proposed to be: Vibration and cold affect the local vessels and nerves directly, leading to enhanced release of chemical vasoconstrictors. Vibration, noise, cold, ergonomic and biodynamic conditions, and emotional stress during work result in disorders of the central and autonomic nervous systems. In the early stages, the autonomic nervous system may be stimulated, and in the later stages it is suppressed. When local vessel injuries and disorders of the central and local autonomic nervous mechanisms controlling the vessels occur, vasospasms in the fingers develop when the whole body is exposed to cold. The cardiovascular system, other than the peripheral circulatory system, may adapt to vibration stress. The adaptation subsides 7 to 8 years after discontinuation of the use of hand-held vibratory tools.