Biomaterial Database

A new regulator of the vacuolar H(+)-ATPase in the kidney. 2011

Dominique Eladari, and Jacques Teulon

Centre de Recherche des Cordeliers, Équipe de Recherche Labellisée (ERL) Centre National de la Recherche Scientifique (CNRS) 7226, INSERM UMRS 872 (Équipe 3), Université Pierre et Marie Curie, Paris, France; Département de Physiologie, Hôpital Européen Georges-Pompidou-Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Faculté de Médecine Paris Descartes, Université Paris Descartes, Paris, France. Electronic address: dominique.eladari@crc.jussieu.fr.

Xu et al. identify Slc26a11, a novel member of the Slc26 anion exchanger family, as an electrogenic (Cl(-))(n)/HCO(3)(-) exchanger. Functional characterization of this transporter suggests that Slc26a11 mediates classical electroneutral Cl(-)/HCO(3)(-) exchange but also exhibits an electrogenic Cl(-) conductance. In the kidney, Slc26a11 colocalizes with the vacuolar H(+)-ATPase in intercalated cells, emphasizing the cooperation of the proton pump with chloride transporters.

UI	MeSH Term	Description	Entries
D007685	Kidney Tubules, Collecting	Straight tubes commencing in the radiate part of the kidney cortex where they receive the curved ends of the distal convoluted tubules. In the medulla the collecting tubules of each pyramid converge to join a central tube (duct of Bellini) which opens on the summit of the papilla.	Kidney Collecting Ducts,Kidney Collecting Duct,Collecting Duct, Kidney,Collecting Ducts, Kidney
D002712	Chlorides	Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.	Chloride,Chloride Ion Level,Ion Level, Chloride,Level, Chloride Ion
D000076988	Sulfate Transporters	Highly conserved families of transmembrane anion transporters that occur in both prokaryotes and eukaryotes. In humans, they are expressed by epithelial cells in a variety of tissues and participate in diverse physiologic functions such as cell motility and regulating the composition and acidity of body fluids. Some Slc13 family proteins function as sodium ion-coupled co-transporters of sulfate and other anions.	Slc26 Protein,Slc26 Transporter,Sulfate Transporter,Sulphate Transporter,Slc26 Family,Slc26 Proteins,Slc26 Transporters,Solute Carrier 26 Family,Sulphate Transporters,Protein, Slc26,Transporter, Slc26,Transporter, Sulfate,Transporter, Sulphate,Transporters, Slc26,Transporters, Sulfate,Transporters, Sulphate
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D025262	Vacuolar Proton-Translocating ATPases	Proton-translocating ATPases that are involved in acidification of a variety of intracellular compartments.	Lysosomal F(1)F(0) ATPase,Lysosomal Proton-Translocating ATPases,V-Type ATPase,Vacuolar ATPase,Vacuolar F(1)F(0) ATPase,Vacuolar F(1)F(0) ATPases,Vacuolar H+-ATPase,Vacuolar Membrane H(+)-ATPase,ATPase, V-Type,ATPase, Vacuolar,ATPases, Lysosomal Proton-Translocating,H+-ATPase, Vacuolar,Lysosomal Proton Translocating ATPases,Proton-Translocating ATPases, Lysosomal,V Type ATPase,Vacuolar H+ ATPase
D027321	Anion Transport Proteins	Membrane proteins whose primary function is to facilitate the transport of negatively charged molecules (anions) across a biological membrane.	Anion Pumps,ATPHPM,Anion Pump,Anion Transport Proteins (Hepatocyte Plasma Membrane),Pump, Anion,Pumps, Anion