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Modulation of c-myc gene expression by extracellular stimuli in H4IIE rat hepatoma cells was investigated by Northern blot analysis. Treatment of these cells with phorbol 12-O-tetradecanoate 13-acetate (TPA), insulin and concanavalin A (Con A) resulted in transient accumulation of c-myc transcripts within 2 hours. The induction of c-myc mRNA was dose dependent with similar responses for all three agents. The maximally induced c-myc mRNA levels varied from 5- to 15-fold of the control. Treatment with cycloheximide (10 micrograms/ml) and H7, a protein kinase C inhibitor (20 microM), inhibited this induction, suggesting that c-myc induction by these agents requires protein synthesis and protein kinase C activation.
S Morimura, and
K Kato, and
F Tashiro, and
Y Ueno
April 1990,
Cancer biochemistry biophysics,
S Morimura, and
K Kato, and
F Tashiro, and
Y Ueno
October 1985,
Biochemical and biophysical research communications,
S Morimura, and
K Kato, and
F Tashiro, and
Y Ueno
March 1991,
Zhonghua bing li xue za zhi = Chinese journal of pathology,
S Morimura, and
K Kato, and
F Tashiro, and
Y Ueno
January 2002,
Cell biology international,
S Morimura, and
K Kato, and
F Tashiro, and
Y Ueno
April 1993,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
S Morimura, and
K Kato, and
F Tashiro, and
Y Ueno
September 1991,
The Journal of biological chemistry,
S Morimura, and
K Kato, and
F Tashiro, and
Y Ueno
March 1990,
Japanese journal of cancer research : Gann,
S Morimura, and
K Kato, and
F Tashiro, and
Y Ueno
August 1993,
Endocrinology,
S Morimura, and
K Kato, and
F Tashiro, and
Y Ueno
March 2001,
Immunology letters,
S Morimura, and
K Kato, and
F Tashiro, and
Y Ueno
April 1993,
Proceedings of the National Academy of Sciences of the United States of America,
