Biomaterial Database

[Osseointegration of ceramic cement-free acetabular cups]. 2012

U Schreiner, and A Schulze, and G Scheller, and C Apruzzese, and M L Schwarz

Orthopädisch-Unfallchirurgisches Zentrum, Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer 1, Mannheim.

BACKGROUND A stable osseointegration of an alumina-matrix-composite-ceramic (AMC) could facilitate the use of a thin-walled monoblock acetabular cup for hip arthroplasty with large ball-heads providing advantages like reduced risk of dislocation. The aim of the pilot study was to examine the osseointegration of porous-coated alumina-matrix-composite-ceramic-monoblock cups after implantation in a sheep model. METHODS The porous coated AMC-ceramic cups were taken out after a healing period of 8 and 52 weeks after unilateral implantation in 5 and 6 sheep, respectively. The osseointegration was analysed histomorphologically and histomorphometrically by representative serial sections after dying according to Masson-Goldner. The examination was stratified according the pole and the rim areas as a press-fit cup with an extended rim was used. Two animals had a hip dislocation after 8 weeks and these animals were excluded from the study and replaced. RESULTS The cups were appraised as stable in the bony bed. Histologically, the rim area of the acetabular cup showed a higher osseointegration rate than the pole area. The rate of osseointegration in total was 3% after 8 weeks and 7% after 52 weeks. The rim area furnished 5.1% after 8 and 8.6% after 52 weeks. At the pole the osseointegration was 1,2% after 8 and 5.5% after 52 weeks. No significant differences were seen between both assessed time periods regarding the osseointegration rates. The bone showed an interlocking aspect with the pores of the coating as bony tissue was determined in the pores. CONCLUSIONS The presented pilot study revealed a stable osseointegration of porous-coated AMC-ceramic monoblock cups one year after surgery in a weight-bearing animal model. Interlocking of bone and porous coating may provide a stable osseointegration in the presence of low osseointegration rates, whose enhancement seems to be preferable.

UI	MeSH Term	Description	Entries
D010865	Pilot Projects	Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.	Pilot Studies,Pilot Study,Pilot Project,Project, Pilot,Projects, Pilot,Studies, Pilot,Study, Pilot
D002484	Cementation	The joining of objects by means of a cement (e.g., in fracture fixation, such as in hip arthroplasty for joining of the acetabular component to the femoral component). In dentistry, it is used for the process of attaching parts of a tooth or restorative material to a natural tooth or for the attaching of orthodontic bands to teeth by means of an adhesive.	Cementations
D002516	Ceramics	Products made by baking or firing nonmetallic minerals (clay and similar materials). In making dental restorations or parts of restorations the material is fused porcelain. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Boucher's Clinical Dental Terminology, 4th ed)	Ceramic
D006622	Hip Prosthesis	Replacement for a hip joint.	Femoral Head Prosthesis,Femoral Head Prostheses,Hip Prostheses,Prostheses, Femoral Head,Prostheses, Hip,Prosthesis, Femoral Head,Prosthesis, Hip
D000077	Acetabulum	The part of the pelvis that comprises the pelvic socket where the head of FEMUR joins to form HIP JOINT (acetabulofemoral joint).	Acetabula,Cotyloid Cavity,Acetabulas,Acetabulums,Cavities, Cotyloid,Cavity, Cotyloid,Cotyloid Cavities
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012756	Sheep	Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.	Ovis,Sheep, Dall,Dall Sheep,Ovis dalli
D016348	Osseointegration	The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).	Peri-implant Endosseous Healing,Endosseous Healing, Peri-implant,Endosseous Healings, Peri-implant,Healing, Peri-implant Endosseous,Healings, Peri-implant Endosseous,Peri implant Endosseous Healing,Peri-implant Endosseous Healings
D016896	Treatment Outcome	Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.	Rehabilitation Outcome,Treatment Effectiveness,Clinical Effectiveness,Clinical Efficacy,Patient-Relevant Outcome,Treatment Efficacy,Effectiveness, Clinical,Effectiveness, Treatment,Efficacy, Clinical,Efficacy, Treatment,Outcome, Patient-Relevant,Outcome, Rehabilitation,Outcome, Treatment,Outcomes, Patient-Relevant,Patient Relevant Outcome,Patient-Relevant Outcomes
D019544	Equipment Failure Analysis	The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.	Materials Failure Analysis,Prosthesis Failure Analysis,Analysis, Equipment Failure,Analysis, Materials Failure,Analysis, Prosthesis Failure,Analyses, Equipment Failure,Analyses, Materials Failure,Analyses, Prosthesis Failure,Equipment Failure Analyses,Failure Analyses, Equipment,Failure Analyses, Materials,Failure Analyses, Prosthesis,Failure Analysis, Equipment,Failure Analysis, Materials,Failure Analysis, Prosthesis,Materials Failure Analyses,Prosthesis Failure Analyses