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The present studies were undertaken to investigate whether or not decreased ambulatory activity, including abnormal feeding behavior in diabetic rats, will be simultaneously normalized by insulin administration. To do this, we used the Gunma University-type automatic apparatus for continuous and direct measurement of ambulation and drinking. In this study, 3 U NPH insulin were administered at 1800, just before the dark phase, and 2 U were administered at 0600, just before the light phase. With these insulin doses, we found that 5 weeks were needed to normalize ambulatory activity, 4 weeks were necessary for food intake, 6 weeks for drinking and 2 weeks for body weight. Since ambulatory activity is reported to be related to changes in dopamine turnover, further studies are in progress to determine whether or not dopamine turnover is normalized when there is no difference in ambulatory activity due to insulin replacement.
Y Shimomura, and
M Takahashi, and
H Shimizu, and
N Sato, and
Y Uehara, and
M Negishi, and
T Inukai, and
I Kobayashi, and
S Kobayashi
July 1992,
Diabetes,
Y Shimomura, and
M Takahashi, and
H Shimizu, and
N Sato, and
Y Uehara, and
M Negishi, and
T Inukai, and
I Kobayashi, and
S Kobayashi
March 2013,
Journal of the renin-angiotensin-aldosterone system : JRAAS,
Y Shimomura, and
M Takahashi, and
H Shimizu, and
N Sato, and
Y Uehara, and
M Negishi, and
T Inukai, and
I Kobayashi, and
S Kobayashi
April 1993,
Diabetes,
Y Shimomura, and
M Takahashi, and
H Shimizu, and
N Sato, and
Y Uehara, and
M Negishi, and
T Inukai, and
I Kobayashi, and
S Kobayashi
November 2016,
Pharmaceutical biology,
Y Shimomura, and
M Takahashi, and
H Shimizu, and
N Sato, and
Y Uehara, and
M Negishi, and
T Inukai, and
I Kobayashi, and
S Kobayashi
September 2008,
The Journal of steroid biochemistry and molecular biology,
Y Shimomura, and
M Takahashi, and
H Shimizu, and
N Sato, and
Y Uehara, and
M Negishi, and
T Inukai, and
I Kobayashi, and
S Kobayashi
October 1993,
Diabetes,
Y Shimomura, and
M Takahashi, and
H Shimizu, and
N Sato, and
Y Uehara, and
M Negishi, and
T Inukai, and
I Kobayashi, and
S Kobayashi
January 1993,
Diabetes,
Y Shimomura, and
M Takahashi, and
H Shimizu, and
N Sato, and
Y Uehara, and
M Negishi, and
T Inukai, and
I Kobayashi, and
S Kobayashi
January 1995,
Diabetes research and clinical practice,
Y Shimomura, and
M Takahashi, and
H Shimizu, and
N Sato, and
Y Uehara, and
M Negishi, and
T Inukai, and
I Kobayashi, and
S Kobayashi
September 2023,
Applied biochemistry and biotechnology,
Y Shimomura, and
M Takahashi, and
H Shimizu, and
N Sato, and
Y Uehara, and
M Negishi, and
T Inukai, and
I Kobayashi, and
S Kobayashi
October 2000,
Gene therapy,
