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In a double-blind controlled multicentric study involving 94 patients with an intrauterine fetal death, we investigated the efficacy and tolerance of mifepristone (RU 486), a steroid compound that antagonizes progesterone action at the receptor level. Success of treatment was defined as the occurrence of fetal expulsion within 72 hours after the first drug intake. Mifepristone treatment (600 mg per day for 2 days) was considered to be effective in 29 of 46 patients (63%). There were only eight successes in 48 patients (17.4%) in the placebo group (p = 0.001, chi 2 test). Tolerance was good in the mifepristone group. In the placebo group, disseminated intravascular coagulation occurred in one woman for whom the investigator waited several weeks for spontaneous expulsion. This large double-blind controlled study provides evidence that mifepristone is of interest in the management of intrauterine fetal death. It could provide a pharmacologic alternative to the use of prostaglandins in this indication.
D Cabrol, and
C Dubois, and
H Cronje, and
J M Gonnet, and
M Guillot, and
B Maria, and
J Moodley, and
J F Oury, and
J M Thoulon, and
A Treisser
November 1985,
Lancet (London, England),
D Cabrol, and
C Dubois, and
H Cronje, and
J M Gonnet, and
M Guillot, and
B Maria, and
J Moodley, and
J F Oury, and
J M Thoulon, and
A Treisser
January 1992,
Diskussionsforum medizinische Ethik,
D Cabrol, and
C Dubois, and
H Cronje, and
J M Gonnet, and
M Guillot, and
B Maria, and
J Moodley, and
J F Oury, and
J M Thoulon, and
A Treisser
June 1992,
The Western journal of medicine,
D Cabrol, and
C Dubois, and
H Cronje, and
J M Gonnet, and
M Guillot, and
B Maria, and
J Moodley, and
J F Oury, and
J M Thoulon, and
A Treisser
March 1990,
The New England journal of medicine,
D Cabrol, and
C Dubois, and
H Cronje, and
J M Gonnet, and
M Guillot, and
B Maria, and
J Moodley, and
J F Oury, and
J M Thoulon, and
A Treisser
December 1990,
The Medical letter on drugs and therapeutics,
D Cabrol, and
C Dubois, and
H Cronje, and
J M Gonnet, and
M Guillot, and
B Maria, and
J Moodley, and
J F Oury, and
J M Thoulon, and
A Treisser
January 1993,
Archives of family medicine,
D Cabrol, and
C Dubois, and
H Cronje, and
J M Gonnet, and
M Guillot, and
B Maria, and
J Moodley, and
J F Oury, and
J M Thoulon, and
A Treisser
October 2000,
The Medical letter on drugs and therapeutics,
D Cabrol, and
C Dubois, and
H Cronje, and
J M Gonnet, and
M Guillot, and
B Maria, and
J Moodley, and
J F Oury, and
J M Thoulon, and
A Treisser
January 1990,
Zentralblatt fur Gynakologie,
D Cabrol, and
C Dubois, and
H Cronje, and
J M Gonnet, and
M Guillot, and
B Maria, and
J Moodley, and
J F Oury, and
J M Thoulon, and
A Treisser
July 1979,
Nederlands tijdschrift voor geneeskunde,
D Cabrol, and
C Dubois, and
H Cronje, and
J M Gonnet, and
M Guillot, and
B Maria, and
J Moodley, and
J F Oury, and
J M Thoulon, and
A Treisser
January 2007,
Acta obstetricia et gynecologica Scandinavica,
