Fulminant intracranial hypertension due to cryptococcal meningitis in a child with nephrotic syndrome. 2011

Leena Nagotkar, and Preeti Shanbag, and Anupama Mauskar, and Syed Ahmed Zaki, and Chaya A Kumar
Department of Pediatrics and Microbiology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India.

Cryptococcus neoformans has a worldwide distribution. Meningoencephalitis is the most common manifestation of cryptococcosis. The outcome of a patient with cryptococcal infection depends on the immune status of the host. Patients with nephrotic syndrome are particularly susceptible to cryptococcal infection not only due to innate changes in their immune system but also because of the immunosuppressive agents used in the treatment. We report an 8-year-old boy with nephrotic syndrome, who developed cryptococcal meningitis and died of fulminant intracranial hypertension.

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