Neurocognitive development and behavioral outcome of 2-year-old children with univentricular heart. 2011

Riina Puosi, and Marit Korkman, and Anne Sarajuuri, and Eero Jokinen, and Leena Mildh, and Ilkka Mattila, and Tuula Lönnqvist
Division of Child Neurology, Helsinki University Central Hospital, Helsinki, Finland. riina.puosi@hus.fi

Recent advances in the treatment of children with severe congenital heart defects, such as hypoplastic left heart syndrome (HLHS) and other forms of univentricular heart (UVH), have significantly improved their survival rates. However, these children are at risk for various neurodevelopmental deficits. The aim of the present study was to assess cognitive development, expressive language, and behavior in 30-month-old children with univentricular heart. The participants were 22 children with HLHS, 14 with UVH, and 41 healthy control subjects. The Bayley Scales of Infant Development II, MacArthur Communicative Development Inventories, and Child Behavior Checklist were used for assessments. The results revealed that children with HLHS exhibited a significantly lower mean mental development index, more delays in expressive language functions, and more behavioral problems than did the control children. Two children with HLHS (9%) had mental development indexes below 50, indicating significantly delayed performance. The children with UVH differed from the control children with respect to their lower mean mental development index. These findings suggest that at the age of 30 months, neurodevelopmental deficits are especially prevalent in children with HLHS. Thus, early developmental screening, intervention, and neuropsychological follow-up until school age is recommended particularly for the children with HLHS.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007805 Language Development Disorders Conditions characterized by language abilities (comprehension and expression of speech and writing) that are below the expected level for a given age, generally in the absence of an intellectual impairment. These conditions may be associated with DEAFNESS; BRAIN DISEASES; MENTAL DISORDERS; or environmental factors. Language Delay,Speech Delay,Auditory Processing Disorder, Central,Central Auditory Processing Disorder,Developmental Disorder, Speech or Language,Developmental Language Disorders,Language Disorders, Developmental,Semantic-Pragmatic Disorder,Speech or Language, Developmental Disorder,Delay, Speech,Delays, Speech,Development Disorder, Language,Developmental Language Disorder,Disorder, Language Development,Disorders, Language Development,Language Delays,Language Development Disorder,Language Disorder, Developmental,Semantic Pragmatic Disorder,Semantic-Pragmatic Disorders,Speech Delays
D008297 Male Males
D009460 Neurologic Examination Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system. Examination, Neurologic,Neurological Examination,Examination, Neurological,Examinations, Neurologic,Examinations, Neurological,Neurologic Examinations,Neurological Examinations
D009483 Neuropsychological Tests Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury. Aphasia Tests,Cognitive Test,Cognitive Testing,Cognitive Tests,Memory for Designs Test,Neuropsychological Testing,AX-CPT,Behavioral Assessment of Dysexecutive Syndrome,CANTAB,Cambridge Neuropsychological Test Automated Battery,Clock Test,Cognitive Function Scanner,Continuous Performance Task,Controlled Oral Word Association Test,Delis-Kaplan Executive Function System,Developmental Neuropsychological Assessment,Hooper Visual Organization Test,NEPSY,Neuropsychologic Tests,Neuropsychological Test,Paced Auditory Serial Addition Test,Repeatable Battery for the Assessment of Neuropsychological Status,Rey-Osterrieth Complex Figure,Symbol Digit Modalities Test,Test of Everyday Attention,Test, Neuropsychological,Tests, Neuropsychological,Tower of London Test,Neuropsychologic Test,Test, Cognitive,Testing, Cognitive,Testing, Neuropsychological,Tests, Cognitive
D002653 Child Behavior Disorders Disturbances considered to be pathological based on age and stage appropriateness, e.g., conduct disturbances and anaclitic depression. This concept does not include psychoneuroses, psychoses, or personality disorders with fixed patterns. Childhood Behavior Disorders,Behavior Disorder, Child,Behavior Disorder, Childhood,Child Behavior Disorder,Childhood Behavior Disorder,Disorder, Childhood Behavior
D002658 Developmental Disabilities Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed) Child Development Deviations,Child Development Disorders,Child Development Disorders, Specific,Developmental Delay Disorders,Disabilities, Developmental,Development Disorders, Child,Child Development Deviation,Child Development Disorder,Development Deviation, Child,Development Deviations, Child,Development Disorder, Child,Developmental Delay Disorder,Developmental Disability,Deviation, Child Development,Disability, Developmental
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D003072 Cognition Disorders Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment. Overinclusion,Disorder, Cognition,Disorders, Cognition
D005260 Female Females

Related Publications

Riina Puosi, and Marit Korkman, and Anne Sarajuuri, and Eero Jokinen, and Leena Mildh, and Ilkka Mattila, and Tuula Lönnqvist
January 2016, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Riina Puosi, and Marit Korkman, and Anne Sarajuuri, and Eero Jokinen, and Leena Mildh, and Ilkka Mattila, and Tuula Lönnqvist
January 2013, International journal of general medicine,
Riina Puosi, and Marit Korkman, and Anne Sarajuuri, and Eero Jokinen, and Leena Mildh, and Ilkka Mattila, and Tuula Lönnqvist
February 1985, Shika gakuho. Dental science reports,
Riina Puosi, and Marit Korkman, and Anne Sarajuuri, and Eero Jokinen, and Leena Mildh, and Ilkka Mattila, and Tuula Lönnqvist
April 2023, Environment international,
Riina Puosi, and Marit Korkman, and Anne Sarajuuri, and Eero Jokinen, and Leena Mildh, and Ilkka Mattila, and Tuula Lönnqvist
October 2016, Environmental research,
Riina Puosi, and Marit Korkman, and Anne Sarajuuri, and Eero Jokinen, and Leena Mildh, and Ilkka Mattila, and Tuula Lönnqvist
January 2016, Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association,
Riina Puosi, and Marit Korkman, and Anne Sarajuuri, and Eero Jokinen, and Leena Mildh, and Ilkka Mattila, and Tuula Lönnqvist
January 1996, Praxis der Kinderpsychologie und Kinderpsychiatrie,
Riina Puosi, and Marit Korkman, and Anne Sarajuuri, and Eero Jokinen, and Leena Mildh, and Ilkka Mattila, and Tuula Lönnqvist
November 2014, Developmental medicine and child neurology,
Riina Puosi, and Marit Korkman, and Anne Sarajuuri, and Eero Jokinen, and Leena Mildh, and Ilkka Mattila, and Tuula Lönnqvist
April 2016, Cardiology in the young,
Riina Puosi, and Marit Korkman, and Anne Sarajuuri, and Eero Jokinen, and Leena Mildh, and Ilkka Mattila, and Tuula Lönnqvist
January 2016, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Copied contents to your clipboard!