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In aged rats a decrease in axosomatic synapses of granule cells as well as a decrease in the number of synaptic vesicles of giant synapses was found. These phenomena were supposed to be correlated on the basis of a feed-back circuit existing at the level of the dentate gyrus. In fact the axosomatic synapses of the granules are inhibitory gamma-aminobutyric acid-ergic terminals of interneurons. Interneurons receive excitatory afferences from granules via the giant synapses of the mossy fibre collaterals. This results in a feed-back regulation of granule cell activity. The long-term administration of acetyl-L-carnitine to aged rats restores a synaptic pattern comparable to that of young rats. This effect on synaptic plasticity is transient.
R Laschi, and
L Badiali de Giorgi, and
F Bonvicini, and
L Centurione
January 1994,
Experimental gerontology,
R Laschi, and
L Badiali de Giorgi, and
F Bonvicini, and
L Centurione
January 2014,
Hippokratia,
R Laschi, and
L Badiali de Giorgi, and
F Bonvicini, and
L Centurione
January 1989,
Progress in neuro-psychopharmacology & biological psychiatry,
R Laschi, and
L Badiali de Giorgi, and
F Bonvicini, and
L Centurione
January 1989,
Archives of gerontology and geriatrics,
R Laschi, and
L Badiali de Giorgi, and
F Bonvicini, and
L Centurione
November 1991,
Neurology,
R Laschi, and
L Badiali de Giorgi, and
F Bonvicini, and
L Centurione
June 2003,
Journal of medical genetics,
R Laschi, and
L Badiali de Giorgi, and
F Bonvicini, and
L Centurione
February 2001,
Experimental gerontology,
R Laschi, and
L Badiali de Giorgi, and
F Bonvicini, and
L Centurione
February 2009,
Clinical and investigative medicine. Medecine clinique et experimentale,
R Laschi, and
L Badiali de Giorgi, and
F Bonvicini, and
L Centurione
July 1992,
Biological psychiatry,
R Laschi, and
L Badiali de Giorgi, and
F Bonvicini, and
L Centurione
January 1989,
Archives of gerontology and geriatrics,
