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In order to investigate the role of prolactin in the control of the circadian rhythm of plasma aldosterone (PA), plasma renin activity (PRA), cortisol (PC), aldosterone and prolactin (PRL) levels were determined in samples at 4-hour intervals from 5 normal supine men over a period of 24 h under basal conditions and subsequently over a period of 24 h during suppression of prolactin release by bromocriptine (CB-154). After suppression of prolactin, statistically signific1nt circadian rhythms in PC and PA have been detected with a moderate decrease of PA concentration, while the PC level remained unalterated. PRA rhythmicity persisted with a significant shift of acrophase and remarkable reduction of plasma levels. Moreover, during CB administration a significant correlation was obtained between PA and PC, while no correlation was detected between PA and PRA. These data are consistent with the following concepts: (a) the prolactin does not play a significant role in the regulation of circadian rhythm and concentration of plasma aldosterone in normal supine men, and (b) bromocriptine induces a remarkable reduction of PRA and a variable decrease in plasma aldosterone, but it does not influence the secretion of cortisol in normal subjects.
E C degli Uberti, and
B L Fabbri, and
A R Margutti, and
C M Fersini, and
R Pansini
January 1975,
The Journal of clinical endocrinology and metabolism,
E C degli Uberti, and
B L Fabbri, and
A R Margutti, and
C M Fersini, and
R Pansini
October 1974,
Clinical endocrinology,
E C degli Uberti, and
B L Fabbri, and
A R Margutti, and
C M Fersini, and
R Pansini
September 1975,
Acta endocrinologica,
E C degli Uberti, and
B L Fabbri, and
A R Margutti, and
C M Fersini, and
R Pansini
October 1977,
The Journal of clinical endocrinology and metabolism,
E C degli Uberti, and
B L Fabbri, and
A R Margutti, and
C M Fersini, and
R Pansini
June 1975,
The Journal of laboratory and clinical medicine,
E C degli Uberti, and
B L Fabbri, and
A R Margutti, and
C M Fersini, and
R Pansini
November 1975,
Kidney international,
E C degli Uberti, and
B L Fabbri, and
A R Margutti, and
C M Fersini, and
R Pansini
October 1975,
Klinische Wochenschrift,
E C degli Uberti, and
B L Fabbri, and
A R Margutti, and
C M Fersini, and
R Pansini
August 1975,
The Journal of clinical endocrinology and metabolism,
E C degli Uberti, and
B L Fabbri, and
A R Margutti, and
C M Fersini, and
R Pansini
December 1970,
Journal of clinical pathology,
E C degli Uberti, and
B L Fabbri, and
A R Margutti, and
C M Fersini, and
R Pansini
April 1979,
The Journal of clinical investigation,
